Can more sleep help ease pain? Yes, says new study!

Chalk another one up for the benefits of sleep. Researchers at the Sleep Disorders and Research Center at the Henry Ford Hospital in Detroit have found that getting more sleep improves daytime alertness and reduces pain sensitivity in healthy adults.

The study was led by Timothy A. Roehrs, Ph.D. of the Sleep Disorders and Research Center at the Henry Ford Hospital and supported by the Fund for Henry Ford Health System. Roehrs and his colleagues studied 18 pain-free, but mildly sleepy volunteers.

For the study, the participants were randomly assigned to four nights of either their normal amount of sleep, or extending their sleep time to 10 hours in bed per night. Their daytime sleepiness was measured on days one and four using the Multiple Sleep Latency Test (MSLT), a tool that measures how quickly a person falls asleep. Their pain sensitivity was also measured using finger withdrawal latency pain testing to a radiant heat stimulus.

The first study to prove sleep reduces pain.

The results of the study were published in the Dec. 1 issue of the journal Sleep. It is the first research of its kind to prove that extended sleep in mildly sleep-deprived adults can significantly reduce their sensitivity to pain.

The results showed that the extended sleep group—those who slept more than normal—slept 1.8 hours more per night than the normal sleep group. It also showed that they experienced less daytime sleepiness. This increase in sleep time during the four nights correlated to increased daytime alertness, as well as less sensitivity to pain.

Regarding the pain test, the extended sleep group showed a greater tolerance for pain/reduced pain sensitivity. The length of time before participants removed their finger from a radiant heat source increased by 25 percent. The researchers noted that this increase in “finger withdrawal latency” is greater than the effect found in a previous study where participants used 60 milligrams of codeine.

In their report, the researchers stated that the results, combined with data from previous research, suggest that increased pain sensitivity in sleepy individuals is the result of their underlying sleepiness.

Timothy Roehrs, PhD, the study’s principal investigator and lead author said, “The results suggest the importance of adequate sleep in various chronic pain conditions or in preparation for elective surgical procedures. We were surprised by the magnitude of the reduction in pain sensitivity, when compared to the reduction produced by taking codeine.”
Read the press release for the study, “Extended sleep reduces pain sensitivity.”

Lack of sleep and an increase in strokes.

Roehrs’ study adds to growing evidence that more regular, restorative sleep can help reduce the risk of health problems, and the opposite is true, as well.

Last June, the University of Alabama at Birmingham released the results of a study that regularly sleeping less than six hours a night significantly increases the risk of stroke symptoms in middle-age to older adults who are of normal weight and at low risk for obstructive sleep apnea (OSA). That’s worth repeating: Less than six hours of sleep per night increases the risk of strokes in adults of normal weight and not at risk for OSA.
It seems that under six hours of sleep per night is the critical variable, but why? Let’s take a look at the study. The University of Alabama researchers followed 5,666 people  for up to three years who had no history of strokes or stroke-like symptoms, transient ischemic attacks (when blood flow to the brain stops for a brief period causing stroke-like symptoms), or high risk for OSA at the start of the study.

For a period of three years, the researchers followed and studied the subjects’ first stroke symptoms, stroke risk factors, depression symptoms, demographic information and other various health behaviors. What they found was—after adjusting for body-mass index (BMI)—there was a strong association between daily sleep periods of less than six hours and a greater incidence of stroke symptoms for middle-age to older adults, even beyond other risk factors. Interestingly, the researchers did not find any link between short sleep periods and stroke symptoms in overweight and obese participants.

Still, the connection between short sleep and strokes is worthy of great attention from the medical community and general public. I agree with the Alabama study’s lead author, Megan Ruiter, PhD., who said, “The results of the Alabama study provide a strong argument for increasing physician and public awareness of the impact of sleep as a risk factor for stroke symptoms, especially among persons who appear to have few or no traditional risk factors for stroke.”

It looks like the medical community is taking this message to heart, no pun intended. Another study announced in late July is going on at the Alberta Health Services and the University of Calgary. There, Dr. Patrick Hanly of the university’s Hotchkiss Brain Institute is leading a study to learn more about the physiological connection between sleep apnea and stroke—specifically, the brain’s blood flow response in people with and without sleep apnea.

For the study, participants with sleep apnea stay overnight in the sleep laboratory at Calgary’s Foothills Medical Centre, where their breathing and cardiovascular responses are continuously monitored while they sleep. The next day, their brain blood flow response to reduced oxygen levels is assessed while they are awake. Then, the participants receive supplemental oxygen during sleep for two weeks, and are tested again to see if their cerebral defense mechanisms have improved. The researchers are also studying people without sleep apnea to see if their cerebral defense mechanisms function better than in those with sleep apnea. Hanly and team’s theory is that it is the lack of oxygen, or hypoxia, that people with sleep apnea experience during sleep that impairs the body’s normal defense mechanisms in the brain. A better understanding of this connection will lead to better prevention and treatment strategies.

I applaud the work of the Alabama and Calgary researchers. It’s time we all wake up to the health benefits of regular, restorative sleep

For more information, read the University of Alabama at Birmingham study, “Under 6 Hours of Sleep Tops Risks for Stroke in a Low-risk Population.”

Is the quality of your sleep making you gain weight?

How many of us would like to lose a few pounds, but look for external ways—outside of our bodies—to lose weight?  Perhaps we should be looking more inward, not only at our personal diet and exercise levels, but the length and level, or phase, of our sleep.

Recently, I read an article in the American Journal of Physiology – Regulatory, Integrative and Comparative Physiology. In it, researchers from St. Luke's-Roosevelt Hospital and Columbia University in New York shed some light on the link between our length and phase of sleep, and hunger and weight gain.

The researchers investigated the effects of “sleep architecture” on hunger to determine whether specific stages of sleep—not just the duration of sleep—affect the appetite and food cravings in healthy adults.

What they found is compelling, and cause for further attention: the length of time of sleep, as well as the percentage of overall sleep in different sleep stages, are associated with decreased metabolic rate, increased hunger, and increased intake of calories, specifically from fat and carbohydrates.

For the study, head researcher Ari Shechter and his colleagues studied a random sample of 27 healthy adults between the ages of 30 and 45. The participants underwent two six-day periods of laboratory observation, during which they were slept different lengths of time.

During a "habitual sleep" phase, they were allowed to sleep for nine hours; in the "short sleep" phase, they were allowed just four hours of sleep. Each of the two sleep phase studies were separated by four weeks to make sure the participants fully recuperated, and the women were observed at the same phase of their menstrual cycle. The amount of time spent in each sleep phase—stage 1, stage 2, slow wave sleep (SWS), and REM sleep—was recorded.

For the first four days in both sleep phases, the participants ate meals to meet their energy requirements for weight maintenance. On day four, they rated their hunger and level of desire for different foods. On day five, their resting metabolic rate (RMR) was measured, and for the final two days of the sleep phase studies, the participants were allowed to select their own foods.

The researchers then compared the participants' sleep architectures in both the short sleep and habitual sleep conditions. They also analyzed the relationships between sleep architecture, resting metabolic rate, food intake and food desire ratings.

Shechter and his colleagues found that sleep duration is important, but sleep composition—the time and percentage of overall sleep spent in each stage—also plays an important role in the link between sleep and obesity.

Head researcher Shechter explained, “Any number of various factors like obstructive sleep apnea, certain drugs/medications, chronic exposure to short sleep duration, shift work, jet lag, and changes in the scheduling of the sleep episode, can affect sleep stage quantity and distribution. Our data may provide an explanation for the greater obesity prevalence observed within some of these conditions."

Read the full article, “Changes in Sleep Architecture Increase Hunger, Eating.”
The results of this study remind me of another study I blogged about not long ago on “social jetlag,” another reason for all of us to get more sleep.

Social jetlag is a modern syndrome caused by the discrepancy between our internal body clock and our social clock. And according to Professor Till Roenneberg, Ph.D. at the University of Munich’s Institute of Medical Psychology in Germany, that gap between how much sleep we need and how much we’re actually getting is contributing to our global weight gain and the growing worldwide obesity epidemic.

Each of us has a physiological clock, and that internal clock — also known as our circadian rhythm — is regulated by daylight and darkness to prompt us to go to sleep or wake up. We also have a social clock of things that make up our daily lives, such as our work schedules and social calendars.

The problem is, in our modern society of too-late work hours and too much time in front of computer screens, we are listening to our social clocks more than our physiological clocks, causing a greater sleep gap known as social jetlag. As a person’s circadian rhythm gets more out of whack, their physiological clock gets set later and later, keeping them awake into the night, and feeling chronically tired during the day.

In their study, Professor Roenneberg and his fellow researchers in Munich discovered that people with different weekday and weekend sleep schedules—i.e., those with more social jetlag — were three times more likely to be overweight. That is a significant increase worth repeating: Three times more likely to be overweight!

Furthermore, the body mass index (BMI) of the overweight participants tended to increase as the gap between their weekday and weekend sleep clocks widened.
I applaud the efforts of Roenneberg and his team for their work in particular, because they are bringing a public awareness of a growing syndrome that is affecting many people worldwide — not just shift workers or those with irregular work schedules.

So, why does social jetlag cause weight gain? One of the theories is that late hours encourage irregular meal times and late-night eating, when the body has more difficulty digesting and metabolizing food. That translates into body fat. Another is that chronically tired people are less likely to exercise and more likely to smoke and drink, further contributing to weight gain.

Whatever the causes, it is in all our personal best interests to become more aware of our own physiological clocks and get more restful sleep. Doing so can help us all maintain a healthy body weight, avoid many health problems, feel better and live happier, more productive lives.

So, now that you have this new knowledge about sleep, weight gain, I suggest you give yourself a wonderful personal gift: get more sleep, especially during the holiday season, when many people are overeating and busier than usual. Also spend more time outdoors and exercise. More and better sleep is one of the best gifts you can give yourself for the holidays.

Read Professor Roenneberg and his team’s full report entitled, “Social Jetlag and Obesity,” published in the May 10 issue of Current Biology.

Can Bees Teach Us About Sleep, Learning and Memory?

As I’ve mentioned in previous blogs, we live in an exciting time for sleep research—it seems that every month, new studies are being published that provide us greater insight into the causes and treatments for various sleep disorders. And this month was no exception.

In a new article entitled, “Sleep-deprived bees have difficulty relearning”  in The Journal of Experimental Biology, researcher Randolf Menzel of the Institute of Biology in Berlin, Germany explains his four-decade study with bees, and what the results are teaching us about the effect of poor sleep on memory and learning.

The phases of sleep known as rapid eye movement (REM) and slow wave sleep (SWS) are involved in cognitive memory, such as learning motor skills and consciously remembering. As a result, restorative sleep not only rejuvenates us, it also helps consolidate memories.

To learn more about this relationship between the brain, sleep and memory consolidation, Menzel spent the last four decades studying honey bees. Why bees you ask? Well, according to Menzel, they are easy to train and well-motivated. Also, the human brain is too complex to dissect the neurocircuits that are linked to our memories. With bees, Menzel could identify the tiny circuits that control specific behaviors in their brains.

For the study, Menzel and his colleague, Lisa Beyaert, investigated the ability of bees to learn new routes from their beehive to a new feeding site, and second, the effect that loss of sleep would have on the bee's ability to learn the new route.

They provided a hive with a well-stocked feeder and trained the bees to visit the feeder and return home. To track the bees' flight during the experiments, the researchers used tiny radar antennas glued to the backs of the bees.

Once the researchers saw that the bees had memorized the route from the hive to home, they intercepted some of the bees at the feeder and transported them to a new location before releasing them again to find their way home. For the second part of the experiment, the researchers shook the bees awake every five minutes at night.

The researchers found that the insects could remember the way back to the hive after they had found it one time. However, when the scientists interrupted the bees’ sleep just after they had learned a new direct route, the bees were disoriented during the second attempt to return home.

Fewer than half the disoriented bees found their way back to the hive, and it took them twice as long as the bees with the usual amount of sleep. Menzel explained, "Without sleep, the bees are not able to consolidate the memory of the previous experiences with the new experience. Formation of the new memory is only possible during sleep.”

The well-rested bees, on the other hand, were able to find the direct way home after some brief training, but the sleep–deprived bees were disoriented and struggled to find their way. As in humans, sleep helps animals to store new experiences in such a way that earlier memories can be altered and supplemented. In other words, sleep helps us create new memories that override the previous memories.

So, what can bees teach us from Menzel’s study? That healthy, restorative sleep is vital to learning and consolidating memories. So get some good sleep tonight. That goes for you too, bees.

Read more about Menzel’s study in the article, “Sleep-deprived bees have difficulty relearning” in The Journal of Experimental Biology.

Veterans with Sleep Apnea: A Growing Human Issue

Whether or not you personally know someone who has served in Iraq, Afghanistan or someplace else on foreign soil, our returning veterans deserve our help and attention. While many have the scars of physical injury, many more veterans bear silent scars. A little known fact but of increasing concern in the medical community is that a growing number of veterans are suffering from obstructive sleep apnea (OSA), and its symptoms can be devastating for our returning war heroes as they readjust to civilian life

Consider these statistics: According to the U.S. Department of Veterans Affairs (VA), one out of every five war veterans has been diagnosed with OSA — compared with only five out of 100 civilians in the general population. And between 2008 and 2010, the number of veterans who received medical benefits related to sleep apnea grew by 61 percent, from 39,145 cases in 2008 to 63,118 cases in 2010.

These numbers beg the question: Why do war veterans suffer from sleep apnea more than non-war veterans and civilians? Some VA doctors believe that it is due to the high number of repeat deployments to Iraq and Afghanistan — soldiers are being exposed to higher levels of dust, smoke, stress and violence.

But what is at the core of this connection between war, OSA and other related conditions, such as daytime sleepiness, memory loss, a decrease in work productivity, obesity, heart disease, diabetes, and hypertension. Researchers at the Wayne State University (WSU) School of Medicine are beginning to find out.

Since the mid-2000s, WSU researchers have been studying 145 American immigrants who left Iraq before the 1991 Gulf War, and 205 who fled Iraq after the Gulf War began. All lived in the Detroit area at the time, and were asked about socio-demographics, pre-migration trauma, how they rated their current health, physician-diagnosed and physician-treated OSA, and any somatic and psychosomatic disorders.

The study’s lead investigator, Bengt Arnetz, M.D., Ph.D., M.P.H., School of Medicine professor of occupational and environmental health, and deputy director of the Institute of Environmental Health Sciences at Wayne State said, “It may be the stress of war that leads to fractured sleep, and that no one had explored this possible link before, although basic research suggests it as plausible.”

The results of the study are published in the October 2012 issue of Psychosomatic Medicine in the article, "Obstructive Sleep Apnea, Post-traumatic Stress Disorder, and Health in Immigrants.” The research showed that those who left Iraq after the war began and suffered from mental disorders such as post-traumatic stress disorder (PTSD) and depression, and self-rated their physical health as worse than their actual health, were 43 times more likely than pre-Gulf War immigrants to report OSA and later develop major chronic health issues, such as cardiovascular disease.

On the results, Arnetz said, “It's a known fact that the more exposure to violence you have, the more likely you are to report post-traumatic stress disorder (PTSD) and depression, and the worse your self-rated health is, the more likely your actual health will suffer in five to 10 years.” And I reiterate, those who were exposed to the violence of the war in Iraq were almost twice as likely to experience PTSD and depression, but also Obstructive Sleep Apnea and other chronic health conditions. I applaud Arnetz and his colleagues’ efforts, and encourage them to continue their studies so that we in the medical community can better understand, diagnose and treat war- and stress-related health conditions.

What about treatment? Diagnosing OSA in veterans can be trickier than non-veterans because of the possibility of other military-related medical conditions, such as PTSD. In addition, some military veterans suffering from OSA may underestimate the health benefits of restorative sleep, rather than be properly diagnosed and treated since its common during deployment to have fractured sleep patterns.

The good news is that there is more awareness of OSA than ever before, especially within the military. Back in February 2012, Ventus Medical, the company that makes Provent Therapy, announced that the U.S. Department of Veterans Affairs approved a multi-year, Federal Supply Schedule contract that would enable more veterans to get Provent Therapy treatment — a small, non-invasive nasal device for the treatment of obstructive sleep apnea (OSA).

This is good timing, considering that a substantial percentage of veterans don't accept or adhere to continuous positive airway pressure (CPAP) therapy, even though it is a safe and effective treatment. According to Richard B. Berry, M.D., Professor of Medicine at University of Florida, "There is a great need for access to new, clinically-proven therapies—particularly easy-to-use treatments — for the increasing number of veterans with obstructive sleep apnea."

As more and more Iraq and Afghanistan veterans are realizing their post-war health problems, and because many Vietnam veterans are getting older, the number of veterans applying for OSA-related disability benefits will only continue to rise in the coming years. While OSA is a chronic condition creating a significant burden on the Veterans Healthcare System — the VA spends upwards of $500 million a year to treat veterans with sleep apnea — I believe that it is our duty as a nation to provide proper OSA treatment to our veterans to prevent additional chronic health issues. To read more about the study, go to the Wayne State University website.

Adolescents, Poor Sleep and the Toll on Their Health

Most people consider sleep disorders such as sleep apnea, snoring and poor quality sleep an adult health issue, but research is mounting that young people may suffer from sleep disorders as much as adults do.

Earlier this year, Penn State researchers published the results of a study which showed that children who have learning, attention and/or behavior problems may be suffering from a condition known as excessive daytime sleepiness (EDS)—even if tests indicate that they are getting enough sleep at night.

And The New York Times article from April 16, 2012 entitled “Attention Problems May Be Sleep Related”  also examined the relationship between children’s sleep quality and the ability to pay attention at school.

The article was on another recent study called “Sleep-Disordered Breathing in a Population-Based Cohort: Behavioral Outcomes at 4 and 7 Years,” published in the Official Journal of the American Academy of Pediatrics.

One researcher in the article noted that cases of attention deficit hyperactivity disorder (A.D.H.D.) in children may have been misdiagnosed—that the cause of behavior such as moodiness and hyperactivity might have been due to obstructive sleep apnea (OSA) or other sleep disorder, which caused sleep deprivation in the child. Worse, the drugs prescribed for the misdiagnosed A.D.H.D. might actually be making the child’s symptoms worse.

Now, new research from The Hospital for Sick Children (SickKids) in Toronto found a link between poor sleep quality in adolescents and a host of negative health issues, including higher cholesterol levels, higher body mass index BMI, larger waist size, higher blood pressure, increased risk of hypertension and cardiovascular disease later in life.

The hospital is one of Canada’s most research-intensive hospitals, and is recognized as one of the world’s foremost pediatric health-care institutions. For the study, lead researcher Dr. Indra Narang, Director of Sleep Medicine and Staff Respirologist at SickKids, and her colleagues studied 4,104 adolescents in the Healthy Heart Schools' Program that screens and identifies teens at risk of coronary vascular disease.

The young participants slept an average of 7.9 hours during the week, and 9.4 hours on weekends. Their sleep patterns, length and quality of sleep were recorded, and data was collected on their BMIs, cholesterol levels and blood pressures. They also found out if any participants had a family history of premature cardiovascular disease.

The results of the study were published in the October 1 edition of the CMAJ — Canadian Medical Association Journal. Almost 20 percent of the adolescents reported poor sleep quality during the week, and 10 percent reported poor sleep quality on weekends. Of the participants, almost 6 percent reported using medications to help them sleep.

From the data collected, the researchers found a link between poor sleep quality—also known as sleep disturbance—and cardiovascular risk in adolescents, based on high cholesterol levels, increased BMI and hypertension. In addition, researchers found a higher sleep disturbance score in adolescents with higher cholesterol level, higher BMI, larger waist size, higher blood pressure and increased risk of hypertension.

Higher sleep disturbance scores were also found in the adolescents who consumed more fried foods, soft drinks, sweets and caffeinated drinks, exercised less and spent more time in front of computer screens. Shorter sleep duration was also associated with higher BMI and waist size. While more research is needed, the findings of the study add to compelling evidence that poor sleep quality in young people is a problem that should be addressed.
Parents, caretakers, teachers and doctors should take a young person’s “sleepy” complaints seriously, and look for clues in their behavior that may indicate sleep deprivation, including excessive daytime sleepiness and symptoms such as inattentive behavior, trouble learning and paying attention, and weight gain/obesity.

I agree with Dr. Brian McCrindle, senior author and cardiologist at SickKids, who recommends that parents do what they can now to help improve the sleep habits of children early in life, such as monitor their caffeine intake and bedtimes, and make sure their bedrooms do not have too much media, especially late at night. Doing so can help ensure that a child’s neurobehavioral challenges are properly diagnosed and treated, leading to better behavior, greater ability to learn and a happier child.

Read the full report, “Poor sleep in adolescents may increase risk of heart disease.”

Women, Wake Up: Sleep Apnea is Not Just a Male Disorder

Earlier this year, a particularly alarming statistic came out of Valme University Hospital in Seville, Spain, where researchers found that women with untreated severe OSA are three and a half times more likely to die from cardiovascular disease than women without OSA. (Read a summary of the study here.)

Since then, more research has been published showing high rates of sleep apnea in women,  as well as increasing links between OSA and age, obesity and hypertension.

In one new study published in August, researchers from Uppsala and Umeå University in Sweden analyzed 400 women between the ages of 20 and 70 years. They found that OSA was present in 50 percent of ALL the women participants aged 20 to 70 years.

They also found that 80 percent of women with hypertension and 84 percent of obese women suffered from sleep apnea. Of the obese women, 31 percent between age 55 and 70 had severe sleep apnea.

The alarming high percentages show that this should be a wake-up call to women.  Sleep apnea is not just a male disorder. Women—especially those with hypertension and/or obesity—need to wake up to the dangers of OSA and seek treatment if diagnosed with it.

Even Dr. Karl Franklin, lead author of the Swedish study, was surprised by the findings. He said, “We were very surprised to find such a high occurrence of sleep apnea in women, as it is traditionally thought of as a male disorder. These findings suggest that clinicians should be particularly aware of the association between sleep apnea and obesity and hypertension, in order to identify patients who could also be suffering from the sleeping disorder.

I agree wholeheartedly with Dr. Franklin, and add to his point that individuals, not just doctors, also need to be aware and speak up if they suspect they may have sleep apnea and related conditions. Read a summary of the study.

A few more recent studies showing OSA’s link to women’s health issues:

A study published in the September issue of the journal Obstetrics & Gynecology out of the University of South Florida found that babies born to obese women with OSA were more likely to be admitted to the neonatal intensive care unit than babies born to women without OSA. In addition, the women with OSA were more likely to develop a high blood pressure condition during pregnancy known as preeclampsia, and to deliver their babies by cesarean section.

Read the study, entitled, “Sleep apnea in obese pregnancy women linked to poor maternal and neonatal outcomes.”

In another study also published in September, sleep apnea in women has been linked to overactive bladder syndrome.

Researchers from the Hospital del Mar in Barcelona, Spain gave 72 women a questionnaire regarding their bladder control and four specific symptoms. According to the results, 62 of the women polled were diagnosed with obstructive sleep apnea (OSA). Further, the women with OSA scored higher on the questionnaire for the prevalence of bladder control symptoms, and the discomfort related with these symptoms.

More research is needed, but clearly, evidence is mounting showing the link between women and sleep apnea, and related disease and disorders. With one in four women over age 65 suffering from sleep apnea, according to the National Sleep Foundation, every woman who believes she is suffering from a sleep disorder-related condition should learn more and get checked out by a qualified sleep doctor. Many women are selfless caretakers, and will put their own worries or needs aside to take care of the needs of others. But don’t wait: Your health is the most important thing, and the healthier you are, the more productive you’ll be and the better you can care for your loved ones.

How do you know you may have obstructive sleep apnea? Some common symptoms include snoring, paused breathing during sleep and excessive sleepiness during the day. If you or someone you know is waking during the night gasping for air, that is a signal to seek diagnosis. Increased blood pressure is another sign you may have sleep apnea. For further study, read “Women and Sleep”  on the National Sleep Foundation website.

When you go for an exam, be specific with your doctor about the symptoms you are experiencing. While sleep apnea is more common in men, OSA increases in women after age 50. Many times, obstructive sleep apnea can be misdiagnosed in women as chronic fatigue, insomnia, depression, or some other non-specific condition. Also, some doctors still associate sleep apnea more with men than women, and are too quick to prescribe a medication, rather than do a full sleep disorder work up. Be  as clear and detailed as you can about your symptoms and what you are experiencing, and don’t wait —it could save your life.

Light from Tablet Computers May Delay Sleep, Especially in Teens

I admit I love my gadgets – especially my laptop and e-reader, I’m also, as a doctor, aware of the effects that the artificial light from these devices can have on our sleep, especially following prolonged and late-night use.

The artificial, short-wave light from TV and computer screens can suppress melatonin production and throw off circadian rhythm, preventing deep, restorative sleep. Prolonged sleep disruption may also lead to increased risk for diabetes and obesity.  A new study  released in late August reinforces my opinion with some data.

Researchers at the Lighting Research Center (LRC) at Rensselaer Polytechnic Institute in Troy, NY tested the effects of self-luminous tablets on melatonin suppression. Melatonin is a hormone produced by the pineal gland at night and is involved in regulating our sleeping and waking cycles.

The study was funded by Sharp Laboratories of America and led by Mariana Figueiro, associate professor at Rensselaer and director of the LRC’s Light and Health Program. Co-authors of the study are LRC director and professor Mark S. Rea, LRC research specialist Brittany Wood, and LRC research nurse Barbara Plitnick.

For the study, 13 participants used self-luminous tablets to read, play games and watch movies. The participants were divided into three groups. The first group viewed their tablets through a pair of clear goggles fitted with blue light. This was the “true positive” group because blue lights are known to be a strong stimulus for suppressing melatonin.

The second “control” group viewed their tablets through orange-tinted glasses, which filtered out the short-wavelength radiation that can suppress melatonin. The third group did not wear any glasses or goggles. Each tablet was set to full brightness.

The results of the study were clear: After only two hours of exposure to electronic devices with self-luminous “backlit” displays, the participants’ melatonin levels were suppressed by about 22 percent. According to lead researcher Mariana Figueiro, stimulation of the circadian system to this level may delay sleep in those using the devices prior to bedtime, especially in teens.

The researchers also determined that the type of task being performed on the tablets also determines how much light is delivered to the cornea, and therefore the impact the self-luminous light has on nighttime melatonin levels. In other words, the researchers pointed out that it is important to measure how much light a person receives from the self-luminous device.

So, what can be done with this new information? How can we use it to improve our sleep and general health? One, we can all become more aware of how much time we—and our children—spend staring at our tablets, computer and TV screens late at night. As adults, it is up to us to monitor ourselves and our children, and have the discipline to turn these machines off at least an hour before bedtime.

LRC research specialist Brittany Wood said, “Technology developments have led to bigger and brighter televisions, computer screens, and cell phones. To produce white light, these electronic devices must emit light at short wavelengths, which makes them potential sources for suppressing or delaying the onset of melatonin in the evening, reducing sleep duration and disrupting sleep. This is particularly worrisome in populations such as young adults and adolescents, who already tend to be night owls.”

Although pre-teens and teens love their late-night electronics, as parents, it is our responsibility to monitor our children’s computer use, or at the very least in older teens, educate them and make them aware of the potential; side effects of prolonged use.

Researcher Figueiro also feels that tablet display manufacturers can use this information to determine how their products affect circadian system regulation, and as a result, design more “circadian-friendly” electronic devices that could either increase or decrease circadian stimulation depending on the time of day. For example, screens that reduce circadian stimulation in the evening for a better night’s sleep, and increasing in the morning to encourage alertness.

Figueiro had another interesting idea about tablet light therapy: In the future, manufacturers might be able to use related data to design tablets that minimize symptoms of seasonal affective disorder, and sleep disorders in seniors. People might even be able to receive light treatments while playing games or watching movies, making light therapy much more enjoyable than just sitting in front of a light box.

Until manufacturers develop more “circadian-friendly” electronic devices that increase or decrease light exposure based on time of day, Figueiro offered several recommendations to reduce the effects of self-luminous tablet light on sleep, including dimming these devices at night as much as possible in order to minimize melatonin suppression, and, as I mentioned before, limiting the amount of time spent using these devices prior to bedtime.

Here’s another idea: Why not turn off the devices before bed, and pick up a good old fashioned paper book. You’ll be out like a light before you know it.

Read the full study entitled, “Light From Self-Luminous Tablet Computers Can Affect Evening Melatonin, Delaying Sleep.”

The Link Between Sleep Apnea and Cancer—Evidence is Mounting

September is back to school month for many of our children — it’s also a good time for adults to learn about health issues, so here is some information to help you become educated about the health risks associated with untreated sleep apnea. Evidence is mounting: severe obstructive sleep apnea (OSA) may be linked to a higher risk of dying from cancer.

The results of three recent studies in Spain were presented in early September at the European Respiratory Society’s (ERS) Annual Congress in Vienna. The data presented by the Spanish researchers reinforces the results of previous studies which show similar links between severe OSA and cancer death. 

While scientists have yet to prove 100% that sleep apnea causes a higher risk of cancer death, more and more studies are showing the link. When obstructive sleep apnea occurs, a person’s airway becomes obstructed during sleep, blocking air flow and causing the person to wake suddenly, often gasping for air. This can happen hundreds of times a night, causing a person’s blood oxygen level to drop abnormally low.

Many researcher theorize that the lack of adequate oxygen supply, known as intermittent hypoxia, caused by OSA causes increased vascular growth and tumor growth because poor breathing fails to oxygenate the cells sufficiently.

Thankfully, people with sleep apnea can be treated using multiple methods. One of the most effective is continuous positive airway pressure (CPAP) therapy, which generates a stream of air to keep the upper airways open during sleep.

Let’s look at some recent sleep apnea and cancer studies out of Spain. Dr. Miguel Angel Martinez-Garcia from La Fe University Hospital in Valencia, Spain, and his fellow researchers studied more than 5,600 sleep apnea patients from seven different sleep clinics in Spain. The researchers measured the severity of a patient’s sleep apnea, based on the number of times during the night that a patient’s blood oxygen level dropped below 90 percent oxygen saturation.

The results of the study showed that people with sleep apnea who spent more than 14 percent of their sleep time with oxygen saturation levels below 90 percent not only had severe sleep apnea, but were approximately double the relative risk of dying due to cancer than people without sleep apnea. The researchers also found a significant increase in the relative risk of dying from cancer in people with less severe sleep apnea. This association was even higher in men and younger people.

Lead researcher Dr. Martinez-Garcia stated that the results do not mean unequivocally that sleep apnea causes cancer—it means the researchers found an association between the two disorders. However, the results of the experiment add to growing evidence that there is a clear link between sleep apnea and cancer mortality. 

Research from two other Spanish studies presented at the European Respiratory Society’s Annual Congress showed an increase in cancer incidence in humans, as well as an association between sleep apnea and the spread of cancer in mice.

The second study showed an increase in all types of cancer in people with severe sleep apnea, even when other factors such as age, sex and weight were taken into account. In a third study, Spanish researchers used mice to study the spread of melanoma skin cancer, and whether this was associated with sleep apnea.

The results showed that the spread of cancer was more abundant in mice that had experienced low levels of oxygen as in sleep apnea, than those who breathed normal air during the experiment.

According to the study’s lead author, Professor Ramon Farre from the University of Barcelona in Spain, the results of the mouse study strongly suggests a link between sleep apnea and the spread of cancer, and encourages further research to better understand the links between sleep apnea and cancer.

I agree with Professor Farre that these recent studies offer compelling evidence, and it is our responsibility in the medical and scientific communities to continue researching and testing to better understand the link between sleep apnea and cancer. 

Read the full study, Sleep Apnoea Linked with Increased Risk of Cancer Death.

Less Than Six Hours Sleep/Night Increases Strokes

Lack of sleep and an increase in strokes. According to new research, the two conditions are very connected, even in otherwise healthy adults.

In early June, the University of Alabama at Birmingham released the results of a study that regularly sleeping less than six hours a night significantly increases the risk of stroke symptoms in middle-age to older adults who are of normal weight and at low risk for obstructive sleep apnea (OSA). That’s worth repeating: Less than six hours of sleep per night increases the risk of strokes in adults of normal weight and not at risk for OSA.

It seems that under six hours of sleep per night is the critical variable, but why? Let’s take a look at the study. The University of Alabama researchersfollowed 5,666 people  for up to three years who had no history of strokes or stroke-like symptoms, transient ischemic attacks (when blood flow to the brain stops for a brief period causing stroke-like symptoms), or high risk for OSA at the start of the study.

For a period of three years, the researchers followed and studied the subjects’ first stroke symptoms, stroke risk factors, depression symptoms, demographic information and other various health behaviors. What they found was—after adjusting for body-mass index (BMI)—there was a strong association between daily sleep periods of less than six hours and a greater incidence of stroke symptoms for middle-age to older adults, even beyond other risk factors. Interestingly, the researchers did not find any link between short sleep periods and stroke symptoms in overweight and obese participants.

Still, the connection between short sleep and strokes is worthy of great attention from the medical community and general public. I agree with the Alabama study’s lead author, Megan Ruiter, PhD., who said, “The results of the Alabama study provide a strong argument for increasing physician and public awareness of the impact of sleep as a risk factor for stroke symptoms, especially among persons who appear to have few or no traditional risk factors for stroke.”

It looks like the medical community is taking this message to heart. Another study announced in late July is going on at the Alberta Health Services and the University of Calgary.  There, Dr. Patrick Hanly of the university’s Hotchkiss Brain Institute is leading a study to learn more about the physiological connection between sleep apnea and stroke—specifically, the brain’s blood flow response in people with and without sleep apnea.

For the study, participants with sleep apnea stay overnight in the sleep laboratory at Calgary’s Foothills Medical Centre, where their breathing and cardiovascular responses are continuously monitored while they sleep. The next day, their brain blood flow response to reduced oxygen levels is assessed while they are awake. Then, the participants receive supplemental oxygen during sleep for two weeks, and are tested again to see if their cerebral defense mechanisms have improved. The researchers are also studying people without sleep apnea to see if their cerebral defense mechanisms function better than in those with sleep apnea. Hanly and team’s theory is that it is the lack of oxygen, or hypoxia, that people with sleep apnea experience during sleep that impairs the body’s normal defense mechanisms in the brain. A better understanding of this connection will lead to better prevention and treatment strategies.

I applaud the work of the Alabama and Calgary researchers. It’s time we all wake up to the health benefits of more–and better—sleep.

For more information, read the University of Alabama at Birmingham study, “Under 6 Hours of Sleep Tops Risks for Stroke in a Low-risk Population.”

Heavy Technology Use linked to Fatigue, Stress and Depression in Young Adults

Modern technology is affecting our sleep. The artificial light from TV and computer screens affects melatonin production and throws off circadian rhythms, preventing deep, restorative sleep.

New research out of the University of Gothenburg, Sweden reinforces this fact, specifically relating to young adults. Doctoral student Sara Thomée and her colleagues at the University of Gothenburg's Sahlgrenska Academy conducted four studies to find out the effects of heavy computer and cell phone use on the sleep quality, stress levels, and general mental health of young adults.

For the study, Thomée and her team asked 4,100 young adults between age 20 and 24 to fill out questionnaires. They also interviewed 32 of them who were considered heavy information and communication technology (ICT) users. The researchers analyzed and compiled the data, and the results revealed that intensive use of cell phones and computers can be linked to an increase in stress, sleep disorders and depressive symptoms in young adults.

Some of the more specific findings are:

• Heavy cell phone use showed an increase in sleep disorders in men, and an increase in depressive symptoms in both men and women. 

• Those constantly accessible via cell phones were the most likely to report mental health issues.  

• Men who use computers intensively are more likely to develop sleeping problems.
• Regular, late night computer use is associated with sleep disorders, stress and depressive symptoms in both men and women.
• Frequently using a computer without breaks further increases the risk of stress, sleeping problems and depressive symptoms in women.
• A combination of both heavy computer use and heavy mobile use makes the associations even stronger.

So, what’s behind this link between technology use and negative health symptoms? The researchers have not yet fully determined why heavy technology users are more likely to have sleep disorders, higher stress and mental health issues, but one theory is that people with these symptoms are more likely to reach out and contact friends and family via technology.

I tend to think that the relationship between technology and stress, sleep disorders and depression has more to do with the overuse of technology in our society, especially among young people. If you’re a parent like I am, than you know first-hand how difficult it can be to get children to turn off the computer or put down their phone and stop texting so you can, just maybe, have a real conversation.

This is a growing and serious public health hazard that should be acknowledged and addressed by both the medical community and technology industry. It’s been scientifically proven that the light from TV and computer screens affects melatonin production and melanopsin stimulation, and throws off our circadian rhythms. This interrupts or prevents deep, restorative sleep, causing an increase in stress and depressive symptoms.

In the words of head researcher Sara Thomée, "Public health advice should therefore include information on the healthy use of this technology.” I couldn’t agree more. Just like alcohol ads, so should technology companies carry warnings on their products and in their advertisements. “Text responsibly.” “Don’t surf, then sleep.” You get the idea.

What can we, as individuals, do to protect our health from the negative impact of the ubiquitous technology in our society? Quite simply, turn it off, and get some good sleep. When you are on the computer for any length of time, take more frequent breaks, and impose limits on the amount of time you spend online. Trust me, the world will wait patiently for another Facebook post or text from you.

Remember, people need an average of seven to eight hours of restful sleep to fully take advantage of its restorative power and avoid daytime symptoms of fatigue. So turn off your TV and computer at least one hour before you go to sleep. Don’t sleep with your cell phone on and next to your bed. (Few things are more frustrating than being awakened in the middle of the night by an unimportant text message.)

Re-claim your bedroom for its intended purpose: restful sleep. Move the TV and computer out of the bedroom, or at the very least, don’t watch TV or work on the computer too close to bedtime. Stick to a bedtime routine. Get at least 7-8 hours of sleep every night. Try to go to sleep and wake up around the same time every day, even on weekends. Try to keep to within 20 minutes of the same time each morning and night.

Before bed, do activities that will promote sleepiness, such as a taking a warm bath, or reading a book or magazine. It also helps to maintain a cool temperature in your bedroom. A cool but comfortable temperature is ideal for sleep. Too warm and you will be fitful, too cold however can be uncomfortable and disturb your sleep.

Exercise regularly but not after the late afternoon. Even though exercise helps regulate sleep, rigorous exercise causes endorphins in the body to circulate which can have a stimulant effect, and keep you awake longer at night.

Stay away from caffeine at night. The effects of caffeine are different from person to person, and may last hours after your last cup of coffee, so make your last cup of coffee, regular tea or soda earlier in the day. Avoid alcohol and medicines that make you drowsy. Even if you think it is helping you fall asleep initially, alcohol and medicines that makes you drowsy may affect your sleep throughout the night.

And finally, if you feel that you are suffering from persistent sleep disorder, get checked out by a qualified sleep doctor. Regular, healthy sleep is one of the best things you can do for your mental and physical health.

Read the full report, entitled, “Intensive Mobile Phone Use Affects Young People´s Sleep.”

Lack of Sleep is Stressing Us Out, New Study Says

Stress in our life is not only caused by what we do and our busy schedules—stress is also caused by what we don’t do, namely, not get enough sleep. A new study by researchers in England and the Netherlands have discovered that a severe lack of sleep creates a response in the immune system that is similar to the body’s immediate response when it experiences a stressful situation. Yes, even lack of sleep is stressing us out.

The study was a joint effort by the Department of Forensic Molecular Biology at the Erasmus MC University Medical Center in Rotterdam and the Centre for Chronobiology, Faculty of Health and Medical Sciences, University of Surrey, and the University of Surrey Clinical Research Centre in England.

So how did the researchers determine this? They compared the white blood cell counts of 15 healthy young men under both normal and severely sleep-deprived conditions.

In the first phase of the study, the men followed a strict schedule of eight hours of sleep per night every day for one week. They were also exposed to at least 15 minutes of outdoor light within the first 90 minutes of waking, and prohibited from using caffeine, alcohol or medication during the final three days of the first week.

The researchers required this in order to stabilize the participant’s circadian clocks and minimize sleep deprivation before the second phase of the study. The researchers then categorized and measured each participant’s white blood cells.

In the second phase of the study, the men stayed awake for 29 continual hours, and their white blood cells were again recorded and compared to the white blood cell numbers collected in the first phase of the study.

According to the researchers, the effect of sleep loss on the white blood cells was immediate. The white blood cells known as granulocytes showed a loss of day-night rhythmicity—the circadian rhythm of the granulocytes slowed—and their numbers also increased, particularly at night. This reaction directly mirrors the body’s white blood cell response to stress.

Read the full study entitled, “Diurnal Rhythms in Blood Cell Populations and the Effect of Acute Sleep Deprivation in Healthy Young Men,” published in the July 2012 issue of the journal, Sleep. 

The results of the study are in line with other previous research that shows a link between lack of sleep and a negative immune system response. In March of this year, the University of Rochester Medical Center published results that showed that the immune system of older adults who do not get enough sleep responds to stress with inflammation, increasing the risk for mental and physical health problems.

These studies and others like them reinforce the fact that more quality, restful sleep not only helps us feel better – it may also help us avoid myriad poor mental and physical health conditions. So, get some sleep out there — you’ll feel less stressed out!

“Social Jetlag” Contributing to Global Weight Gain

Here’s another reason to get more sleep — and another new term to describe one of our modern maladies: “social jetlag.” What exactly is social jetlag? It is a syndrome caused by the discrepancy between our internal body clock and our social clock. And according to Professor Till Roenneberg, Ph.D. at the University of Munich's Institute of Medical Psychology in Germany, that gap between how much sleep we need and how much we’re actually getting is contributing to our global weight gain and the growing worldwide obesity epidemic.

Each of us has a physiological clock, and that internal clock — also known as our circadian rhythm — is regulated by daylight and darkness to prompt us to go to sleep or wake up. We also have a social clock of things that make up our daily lives, such as our work schedules and social calendars. The problem is, in our modern society of too-late work hours and too much time in front of computer screens, we are listening to our social clocks more than our physiological clocks, causing a greater sleep gap known as social jetlag. As a person’s circadian rhythm gets more out of whack, their physiological clock gets set later and later, keeping them awake into the night, and feeling chronically tired during the day.

Professor Roenneberg and his fellow researchers in Munich discovered the negative effects of social jetlag after compiling and studying the sleep habits of more than 65,000 adults over the past 10 years. Roenneberg and his team recorded sleep times and other data of the participants, such as height and weight, and started to draw conclusions.

The results of the study — which you can read in the May 10 issue of Current Biology — showed that people with different weekday and weekend sleep schedules—i.e., those with more social jetlag — were three times more likely to be overweight. That is a significant increase worth repeating: Three times more likely to be overweight!  Furthermore, the body mass index (BMI) of the overweight participants tended to increase as the gap between their weekday and weekend sleep clocks widened.

Two-thirds of participants reported at least one hour's difference in their average weekday and weekend sleep schedules, and more than 10 percent reported three-plus hours difference between their weekday and weekend sleep schedules. Roenneberg and his colleagues also found that people who are chronically sleep-deprived are also more likely to smoke and drink more alcohol and caffeine.

The results of the study are similar to those of previous studies linking a higher body mass index and even diabetes to the irregular sleep schedules and sleep deprivation of shift workers. But I applaud the efforts of Roenneberg and his team for their work in particular, because they are bringing a public awareness of a growing syndrome that is affecting many people worldwide — not just shift workers or those with irregular work schedules.

So, why does social jetlag cause weight gain? One of the theories is that late hours encourage irregular meal times and late-night eating, when the body has more difficulty digesting and metabolizing food. That translates into body fat. Another is that chronically tired people are less likely to exercise and more likely to smoke and drink, further contributing to weight gain.

Whatever the causes, it is in all our personal best interests to become more aware of our own physiological clocks and get more restful sleep. Doing so can help us all maintain a healthy body weight, avoid many health problems, feel better and live happier, more productive lives. In the words of Professor Roenneberg, “Good sleep and enough sleep is not a waste of time but a guarantee for better work performance and more fun with friends and family during off-work times.” Knowledge of the study and an increased awareness of the effects of social jetlag can also have positive effects on the economy and education: Companies can make more informed decisions about employees’ work schedules and schools can make more educated decisions about school hours.

So, now that you have this new knowledge about social jetlag, your physiological and social clocks and how a gap between your weekday and weekend sleep schedules can contribute to your weight gain, what are you going to do about it? I present you with a personal challenge that will only help you feel better. I challenge you to get more sleep. Turn off the TV and computer and go to bed earlier. Forego that invitation for a late-night dinner. Spend more time outdoors, and if you’re stuck in an office all day, try to sit near a window. I promise you, you’ll feel less social jetlag.

To read Professor Roenneberg and his team’s full report entitled, “Social Jetlag and Obesity,” published in the May 10 issue of Current Biology.

Ready to Treat Your Sleep Apnea? You Have Options.

This month’s blog is for anyone who has been diagnosed with obstructive sleep apnea (OSA) and is currently using or considering using a Continuous Positive Airway Pressure (CPAP) machine while sleeping.

Many patients are not happy about the prospect of sleeping with an mask on. If you do opt for CPAP therapy, realize that CPAP machines have come a long way. If you’re adamant you do not want to use a CPAP mask, thankfully, you have options.

First, I want to briefly explain what obstructive sleep apnea does to a person’s nighttime breathing. When you fall asleep, your muscles relax, and the soft palate at the back of the throat can sag. When this happens, the upper airway can become obstructed, causing the soft palate and uvula to vibrate, causing snoring.

When the airway is completely obstructed, breathing stops for a period of time, until the body is jerked awake in reaction. This is obstructive sleep apnea. OSA can cause interrupted breathing hundreds of times a night, usually around 20 seconds per pause.

This paused breathing causes waking through the night, preventing deep, restorative sleep. This often leads to a host of problems, from daytime sleepiness and reduced job performance to hypertension,heart disease, mood and memory problems.

A CPAP machine helps this condition by pumping a continuous flow of air into the nasal passages, keeping the airway open, and preventing or greatly reducing snoring and paused breathing.

Many people don’t like wearing the nasal mask for CPAP therapy. Some feel claustrophobic or claim it causes dry mouth, nasal congestion or skin irritations. Realize there are different machines out there, so it’s important to choose the right machine for you—choose a small, quiet machine with a comfortable mask that fits you well. A humidifier attached to the CPAP machine can reduce throat dryness.

If CPAP therapy is not for you, there are some non-surgical treatment options. One of the latest is the Pillar Procedure, a safe, non-invasive treatment for mild to moderate OSA symptoms. During the Pillar Procedure, three tiny polyester implants are placed into the soft palate through a small delivery tool without incisions or stitches. Over the following weeks, the implants, together with the body's natural fibrotic response, stiffens the upper palate and creates structural support. This reduces the tissue vibration that causes snoring and the tissue collapse that causes obstructive sleep apnea. I do the Pillar Procedure at my Eos Sleep office, and it usually takes around 20 minutes.

Another is a more comfortable alternative to CPAP, called the Provent Device. This FDA-approved treatment involves a small nasal valve that fits into the nostrils and is secured by an adhesive bandage. The valve is powered by your own breathing and creates positive airway pressure much like CPAP, but does not require a machine or mask.

Bilevel Positive Airway Pressure (BiPAP) is similar to CPAP therapy, but the machine has two air pressure levels, one for breathing in and one for breathing out. The air pressure for breathing out is usually set lower than the incoming air, and you may find it more comfortable to breathe out against a lower air pressure.

Whatever OSA treatment option you choose, you owe it to yourself to seek proper treatment and use your chosen therapy regularly.  The benefits are great—snoring and paused breathing will be reduced or eliminated, helping you—and your partner—to sleep and feel better during the day.

Is Excessive Daytime Sleepiness the Cause of Learning and Behavior Problems in Children?

For months now, I have been writing about the studies that are being published—seemingly by the month—linking obstructive sleep apnea (OSA) to more and more medical conditions, including hypertension,heart disease, mood and memory problems.

The latest research didn’t surprise me, but it did upset me more than usual — because it concerns our children, and the negative effects that poor sleep can have on their ability to pay attention, learn and control their behavior.

On May 1, the results of a study by Penn State researchers was published showing that children who have learning, attention and/or behavior problems may be suffering from a condition known as excessive daytime sleepiness (EDS)—even if tests indicate that they are getting enough sleep at night. 

For the study, the researchers conducted sleep testing on 508 children, and asked their parents to report if their child seemed excessively sleeping during the day. Then, the children were divided into two groups: children with excessive daytime sleepiness, and those without EDS. The results, published in the May 2012 issue of SLEEP,  showed that the children in the parent-reported EDS group were more likely to have "neurobehavioral” problems, including behavior/conduct problems, attention/hyperactivity and poorer performance in learning speed and working memory than children without indications of EDS.

What surprised the researchers was that, even if a child was in the EDS group, few also showed signs of short (not enough) sleep when tested. As a result, the researchers did not associate short sleep with any of the learning, attention and behavior problems.

So, what is causing these children’s extensive daytime sleepiness if they are getting enough sleep (at least on paper)? Like in adults, perhaps it is not just the length of sleep time, but the quality of sleep that determines restorative rest, or not.

A New York Times article from April 16, 2012 entitled “Attention Problems May Be SleepRelated”  also examined the relationship between children’s sleep quality and the ability to pay attention at school. The article was on another recent study called “Sleep-Disordered Breathing in a Population-Based Cohort: Behavioral Outcomes at 4 and 7 Years,” published in the Official Journal ofthe American Academy of Pediatrics. 

What I found disturbing about this article was that it pointed out that many cases of attention deficit hyperactivity disorder (A.D.H.D.) in children may have been misdiagnosed—that the cause of behavior such as moodiness and hyperactivity might in fact be due to obstructive sleep apnea (OSA) or other sleep disorder, which is causing sleep deprivation in the child. Worse, the drugs diagnosed for the A.D.H.D. are probably making the child’s symptoms worse!

This should be a call to arms for parents, caretakers, teachers and the medical community. If you know of a child suffering from sleep deprivation and/or extensive daytime sleepiness, and the symptoms that result, such as behavioral and learning problems … speak up and suggest they get tested for a sleep disorder first.

 Impairment due to EDS in daytime cognitive and behavioral functioning can have a significant impact on children's development. This is not to say that A.D.H.D. cannot be a true cause, but misdiagnosis of anyone—especially a child prescribed drugs—should not be tolerated.

Stay aware of the child’s behavior; look for clues, such as inattentive behavior and obesity, take a child’s “sleepy” complaints seriously … and then say something. You could be the reason a child’s neurobehavioral challenges are properly diagnosed and treated, leading to better behavior, greater ability to learn and a happier child.

Read the abstract of the report, “Learning, Attention/Hyperactivity, and Conduct Problems as Sequelae of Excessive Daytime Sleepiness in a General Population Study of Young Children.”

Another Reason: Oxygen Depletion from OSA Linked to Higher Rate of Cancer

Every month, I take time to write these blogs to help educate people about the negative health effects associated with obstructive sleep apnea (OSA), and the importance of getting it properly diagnosed and treated. I hope my point is getting across out there.

If you or someone you love regularly experiences OSA symptoms, such as snoring and disordered (interrupted) breathing, here’s another reason to get it checked out: Two new studies claim that OSA sufferers are more likely to die from cancer.

Their findings are significant because it marks the first time that cancer growth has been associated with sleep apnea in people. In a previous study about a year ago, Spanish researchers had already linked the intermittent lack of oxygen caused by OSA—known as hypoxia—with increased tumor growth in mice. That study also found that the mice had more dead cells, which indicates a more aggressive type of cancer.

In one of the new studies, researchers at the University of Wisconsin School of Medicine and Public Health studied data on about 1,500 state workers who have been taking part in overnight sleep studies every four years since 1989.

The researchers found that people with severe sleep apnea who had the most intermittent disordered breathing problems were almost five times more likely to die from cancer than those without OSA. They also found that people considered to have moderate cases of OSA died of cancer at double the rate than those without OSA at all.

This is consistent with the hypoxemia theory—that an increase of interrupted/disordered breathing is actually contributing to cancer cell growth … because the body is being depleted of oxygen.

What the researchers also discovered—and what I found particularly notable—was that when OSA patients who were being treated with continuous positive airway pressure (CPAP) therapy were removed from the Wisconsin study, the OSA/cancer association increased.  In other words, OSA patients who undergo CPAP treatment—who lower their interrupted/disordered breathing episodes—may likely reduce their risk of dying from cancer due to OSA-related oxygen depletion.

In the second related study, researchers at the Spanish Sleep Network used the hypoxemia index, which measures the amount of time the level of oxygen in a person’s blood drops below 90 percent at night.

The researchers followed more than 5,000 OSA patients for seven years. None of them had any cancer diagnosis when the study began, but they found that those with the most severe forms of sleep apnea had a 65 percent greater risk of developing cancer of any kind. In other words, the greater the extent of oxygen depletion during sleep, the more likely a person was to be diagnosed with cancer during the study.

It should be noted that, in both the Wisconsin and Spanish studies, the researchers only looked at cancer diagnoses and deaths in general, not the specific type of cancer.

The takeaway for all of is that this is one more study … one more reason … for you or someone you love with OSA-related paused/intermittent breathing issues to take sleep apnea seriously and get diagnosed asap.

New Study: Health Effects of Sleep Apnea Evident After One Month

It’s an interesting time in the world of sleep apnea research, a disorder in which a person has periods of slow or paused breathing during sleep. It seems that every month there is a new study showing yet another link between sleep apnea and sleep-disordered breathing (snoring, paused breathing, etc.), and its negative effects on health.

Recent studies have linked obstructive sleep apnea (OSA) to depression, silent strokes and small brain lesions, abnormalities in the blood vessels, high blood pressure, heart disease and strokes, even sudden hearing loss. And women take note: Sleep apnea has been linked to dementia in older women, and another study found that women with untreated severe OSA are three and a half times more likely to die from cardiovascular disease than women without OSA!

Clearly, the link between OSA and an increased risk of stroke has been medically established. But what effect does OSA have on the brain vessels and cerebral circulation? Researchers at the   Baylor College of Medicine in Houston, Texas developed a way to find out.

In late April, a study entitled, “Cerebrovascular Consequences of Obstructive Sleep Apnea” was presented and discussed at the Experimental Biology 2012 meeting at the San Diego Convention Center. The researchers described how they developed a new way to induce the effects of obstructive sleep apnea in mice—specifically, the closure of the airway that results in paused breathing and the physiological side effects of OSA. The new testing model enabled the researchers to mimic the symptoms and effects of OSA in humans, and thus study the results in a controlled environment.

For the study, the researchers induced sleep apnea in the mice while they slept. Surprisingly, they found that—after just one month of induced repeated apneas—the mice’s “cerebral vessel dilatory function” was reduced by as much as 22 percent, and the mice’s cerebrovascular function did not function as normal, or before the apneas.

In other words, after just one month of repeated apneas, after a month of repeated apneas, the blood vessels in the mice’s brains did not work as well as they did.

What are the implications of this study? According to the researchers, one is that the new method of testing provides researchers with a more accurate and complete way to study the effects of sleep apnea on people. The other, which I find compelling, is that only one month of moderate, repeated sleep apnea caused a change in cerebrovascular function which could result in a stroke. It is important to note that the results of the study correlates with other studies that show similar cell dysfunction in arteries, which has caused an increased risk of stroke in OSA patients.

This just reinforces the speed in which sleep apnea can damage the body, and the importance of getting diagnosed and treated as quickly as possible.  The results are also a wake-up call to both sleep and medical doctors that damage to the vascular wall in brain arteries could be a factor predisposing an individual with OSA to stroke. Sleep and medical doctors should be working more in tandem to treat patients.

Again, it is in interesting time for sleep apnea research. And I hope and encourage researchers to continue studying and publishing their results so we can all better understand the symptoms and treatments of this disorder. I believe the need for treatment will only increase with time. As obesity, hypertension and other related conditions continues to plague this country, and as the general population ages, we will see an increase in OSA cases. It is no longer a male condition—women, non-obese people and even children can have OSA.

An estimated 18 million Americans have sleep apnea, including one in four women over 65, according to the National Sleep Foundation. While apnea is more common in men, it increases in women after age 50. And some researchers estimate that up to 85 percent of people with clinically significant sleep apnea have not even been diagnosed yet.

Sleep apnea and other sleep-related disorders are prevalent in our society, and people need to wake up to the symptoms and risks associated with them. (I am on a personal mission to educate people about this, and my blog is one of the ways in which I do so.)

So how do you know if you have sleep apnea? The first step is to become aware of some common symptoms, including trouble falling asleep at night, waking throughout the night, chronic snoring, morning headaches, poor memory, daytime sleepiness/falling asleep during the day, bad moods and irritability, increased depression and trouble concentrating/driving/making decisions.

If you have any of the symptoms mentioned above, and suspect that you may have sleep apnea, please get checked out by a doctor who specializes in sleep disorders. Be specific about the symptoms you are experiencing. Many times, sleep apnea can be misdiagnosed as chronic fatigue, insomnia, depression, or some other non-specific condition. Also, some doctors are too quick to prescribe a medication, rather than do a full sleep disorder work up. Again, to try and avoid misdiagnosis, go to a qualified sleep specialist and be specific about your symptoms. Don’t wait—it could save your life, not to mention help your bedmate keep his or her sanity.

One More Reason to Get Checked: Sleep Deprivation Can Cause Weight Gain

It’s no surprise that I use my blog as a forum to educate you on various sleep disorders, and the many reasons to get them diagnosed and treated properly. At the risk of sounding alarmist, not getting a sleep issue checked out—even one you may think is fairly benign—can have dire consequences.

Conditions such as sleep apnea that cause sleep deprivation are linked to poor concentration and memory, increased risk of diabetes, hypertension and high blood pressure, heart attacks and strokes, depression and sexual dysfunction.

As if these reasons aren’t enough to scare you into getting tested, here’s another one that just came out: Lack of sleep is now linked to overeating, and as a result, weight gain. That information was just announced at the American Heart Association’s Epidemiology and Prevention/Nutrition, Physical Activity and Metabolism 2012 conference in San Diego.

To be more specific, according to the study’s abstract, sleep is an important regulator of metabolism and energy expenditure. When acute sleep deprivation occurs, the hormone leptin is reduced, while the hormone ghrelin is increased, promoting caloric intake, but not energy expenditure. The likely result is weight gain.

A quick lesson in endocrinology:

Leptin and ghrelin are appetite hormones. Leptin helps regulate hunger, appetite, and metabolism. When you have low levels of leptin in the body—perhaps due to sleep deprivation—the hormone will tell receptors in the hypothalamus of the brain, “Hey, I’m hungry, feed me.” Normal healthy levels of leptin, on the other hand, will let the brain know that you’ve had enough and are no longer hungry. 

Ghrelin is known as the hunger hormone because its job is to tell the hypothalamus when you are hungry and need to eat. That is why ghrelin levels are elevated in the body when you are hungry, and decrease after you have eaten. Ghrelin also promotes fat storage, and has been linked to the accumulation of abdominal fat.

It stands to reason, then, that if sleep deprivation reduces leptin—causing you to feel hungry—and increases ghrelin—also causing you to feel hungry and eat, then sleep deprivation is likely to lead to overeating and weight gain.

So, how did the researchers come to this conclusion?

Virend Somers, M.D., Ph.D., professor of medicine and cardiovascular disease at the Mayo Clinic, Rochester, Minnesota and his colleagues conducted an eight night sleep test on 17 people—11 men and six women—between the ages of 18 and 40.

Eight of the subjects in the “random group” were made to sleep less than they normally do, while the other nine in the “control group” slept their normal amount of time.

All subjects were able to eat as much as they wanted throughout the testing periods, and their daily caloric intake was measured. In addition, their daily sleep times and energy expenditures were measured, and their blood was collected at the end of the test period.

The results of the test are interesting: The sleep deprived group—who slept one hour and 20 minutes less than the control group per night—ate around 549 more calories per day than the normal sleep group. However, the sleep deprived group who ate more did not expend much more energy than the normal sleep group.

The conclusion again is: Less sleep, plus more calories and no increased activity equals more weight gain. It’s a vicious cycle. So let’s turn this equation around. When you sleep well and get enough rest, you help your body to function properly, including your appetite, metabolism and the hunger hormones mentioned above.

And so I continue my tireless crusade against sleep disorders. If you’re having trouble sleeping, from sleep apnea, snoring or some other disorder, get it checked out and treated by a qualified sleep doctor. Doing so could save you a lot, including a few notches around your belt.

To read the abstract of the study, see Insufficient Sleep Increases Caloric Intake but not Energy Expenditure.