New study links sleep apnea with higher risk of osteoporosis

By David Volpi, M.D., P.C., F.A.C.S. 

Women and older Americans, take note. There’s new research showing that obstructive sleep apnea (OSA) may raise the risk of osteoporosis, particularly in women or older individuals.

OSA is the most common form of sleep apnea and occurs when a person’s airway becomes blocked, causing repeated, brief interruptions in breathing during sleep. If it goes untreated, OSA can cause myriad health problems, including stroke, cardiovascular disease, heart attacks, and now we learn, osteoporosis.

Osteoporosis is a condition that causes bones to gradually thin and weaken, leaving them susceptible to fractures. About 2 million fractures occur each year due to osteoporosis, and of the estimated 8.9 million Americans affected by osteoporosis, at least 80% are women, according to the International Osteoporosis Foundation.
The results of the OSA-osteoporosis study were published April 15 in the Endocrine Society’s Journal of Clinical Endocrinology & Metabolism (JCEM). For the study, the researchers looked at the medical records of 1,377 people in Taiwan diagnosed with OSA between 2000 and 2008. They then compared those records with around 20,000 people of similar age and gender who did not have OSA.

Over the six years of research, the researchers noticed that people with OSA were 2.7 times more likely to be diagnosed with osteoporosis, and the risk was highest among women and older people with OSA.

One of the study’s main authors is Kai-Jen Tien, MD, of Chi Mei Medical Center in Tainan, Taiwan. Tien commented, “Ongoing sleep disruptions caused by obstructive sleep apnea can harm many of the body’s systems, including the skeletal system. When sleep apnea periodically deprives the body of oxygen, it can weaken bones and raise the risk of osteoporosis.

While the study only indicated a link between OSA and osteoporosis, it did not prove if one condition causes the other. That said, I applaud the research team’s efforts in bringing to light the fact that untreated OSA has far-reaching effects in the body, compromising even the skeletal system. I echo Tien’s advice that, “As more and more people are diagnosed with obstructive sleep apnea worldwide, both patients and health care providers need to be aware of the heightened risk of developing other conditions. We need to pay more attention to the relationship between sleep apnea and bone health so we can identify strategies to prevent osteoporosis.”

Read the full study, “Osteoporosis Risk Heightened Among Sleep Apnea Patients.”

Untreated Sleep Apnea: The Quiet Danger on the Road

By Dr. David O. Volpi

It is common knowledge that untreated sleep apnea can have dire health effects, but researchers in England found out that loss of sleep also increases a person’s risk of nodding asleep at the wheel, and getting in a car accident. That endangers not only the person suffering from the sleep disorder, but any person driving around them at any given time.

The study, which was organized by the European Respiratory Society and the European Sleep Research Society, and presented April 12, 2013 at the Sleep and Breathing Conference in Berlin, determined that people with untreated sleep apnea are more likely to fail a driving simulator test, and report nodding asleep while driving.

Let’s review: What is sleep apnea?

Sleep apnea is a breathing disorder that causes a person’s breathing during sleep to be paused and/or shallow. The pauses generally last 10 to 20 seconds, and in severe cases, can occur hundreds of times a night. With obstructive sleep apnea (OSA), the airway is blocked and/or collapses while sleeping. Air squeezing by the blockage can cause loud snoring and interrupted sleep.

As a result of the paused breathing and/or snoring, many sleep apnea sufferers are woken up throughout the night and spend more time in light sleep, rather than deep, restful REM (rapid eye movement) sleep. This chronic sleep deprivation results in daytime sleepiness, and can negatively affect job performance, mood, reflexes, concentration, and it can lead to hypertension, heart disease, and memory problems.

Testing and results of the study

To determine the effect of untreated sleep apnea on driving, the researchers conducted two separate studies. The first was a driving simulation test where 133 patients with untreated sleep apnea and 89 without sleep apnea were asked to “drive” 90 km—about 55 miles.

Various criteria was recorded, including the participants’ ability to complete the driving distance, their time spent in the middle lane, and any participation in an unprovoked crash or a “veer event” crash.

The results of the driving simulation test showed that:

• Patients with untreated sleep apnea were more likely to fail the driving simulation test—24 percent of the sleep apnea patients failed the test, compared to 12 percent of those without sleep apnea.
• In addition, many patients with untreated sleep apnea were unable to complete the test at all, had more unprovoked crashes, and were unable to follow the clear driving instructions given at the beginning of the simulation test.

In the second study, 118 people with untreated sleep apnea and 69 without sleep apnea completed a questionnaire about their driving behavior, and also took the 90 driving test on the simulator.
The results showed that:

• 35 percent of those with untreated sleep apnea admitted to nodding asleep while at the wheel, and 38 percent of this same group failed the driving simulation test.
• By comparison, only 11 percent of people without sleep apnea said they have nodded off while driving, and none of this group failed the simulator test.

Key differences in the reasons for failure

While some people in the control group (those without sleep apnea) also failed the driving simulator test, the researchers noted key differences in why they failed the test:

• 13 people with untreated sleep apnea did not finish the test because they fell asleep or veered completely off the road.
• 5 people with untreated sleep apnea failed because they spent more than 5 percent of the study outside the lane they had been instructed to stay in.

But in the control group, no one failed the simulation for either of these reasons. Again, no one in the “without sleep apnea” group failed the driving simulation due to falling asleep, veering completely off the road, or driving outside the lane.

Dan Smyth of Sleep Apnea Europe noted, "The dangers of untreated sleep apnea and driving are highlighted in both studies. These studies give weight to the need for provision of sufficient resources for early diagnosis and treatment.

While further investigation is needed to examine the reasons for failure of the simulator tests, I acknowledge the researchers for bringing light to this very dangerous side effect of untreated sleep apnea. of sleep apnea, where effective treatment ensures a return to acceptable risk levels for road users."

Are you at risk for sleep apnea?

So how do you know you may have obstructive sleep apnea? Some common symptoms include snoring, paused breathing during sleep and excessive sleepiness during the day. Increased blood pressure is another sign you may have sleep apnea.

While sleep apnea is more common in men, OSA increases in women after age 50. Being overweight may also increase a woman’s risk of having sleep apnea. Menopausal women are three and a half times more likely to get OSA, possible due to reduced amounts of progesterone.

If you experiencing one or more of the above sleep apnea symptoms on a regular basis, see a qualified sleep doctor to get diagnosed and treated properly. There are multiple options and minimally invasive techniques available today to treat your sleep disorder.

Sleep apnea causes systemic inflammation: CPAP can help

By Dr. David O. Volpi

If you, or someone you know, have been diagnosed with obstructive sleep apnea (OSA), you’re probably familiar with a treatment called CPAP, or Continuous Positive Airway Pressure.

While some people find the mask worn for CPAP treatment uncomfortable—more on that later—it has been proven to be a highly effective way to keep the airways open that become obstructed in sleep apnea patients, and reduce or prevent snoring and paused breathing.

There’s a new study that found that CPAP treatment also reduces the systemic inflammation caused by sleep apnea, usually in the bronchial and nasal passages.

Systemic inflammation is the chronic biological response, or inflammation, of blood vessel tissues due to dangerous or foreign elements, such as pathogens or damaged cells. It is increasingly being recognized that systemic inflammation is a risk factor for a number of health complications, including atherosclerosis, and is a well-established factor in the development of cardiovascular disease.

The new study published March 22 in the Journal of Inflammation found that treating OSA with a CPAP machine helps to lower systemic inflammation, which might prevent some of the other problems associated with OSA. The source of the research was the PubMed, Embase and Cochrane library.

Here’s a refresher on how CPAP machines help OSA patients: When you fall asleep, your muscles relax, and the soft palate at the back of the throat may sag. When this happens, the upper airway can become obstructed, causing the soft palate and uvula to vibrate, causing snoring.

When the airway is completely obstructed, breathing stops for a period of time, until the body is jerked awake in reaction. This is known as obstructive sleep apnea. OSA can cause interrupted breathing hundreds of times a night, usually around 20 seconds per pause. This paused breathing causes waking through the night, preventing deep, restorative sleep. This often leads to a host of problems, from daytime sleepiness and reduced job performance to hypertension, heart disease, mood, and memory problems.

A CPAP machine helps this condition by pumping a continuous flow of air into the nasal passages—via a mask worn at night—keeping the airway open—and preventing or greatly reducing snoring and paused breathing.

To find out if CPAP treatment reduces inflammatory symptoms or “markers” in OSA patients, the researchers pooled data from 24 trials involving more than 1,000 patients. The resulting data suggested that treating OSA with CPAP significantly reduces levels of two proteins associated with systemic inflammation: tumor necrosis factor and C-reactive protein (CRP).

While more study is needed, the researchers believe that reducing systemic inflammation in OSA patients with CPAP treatment may be one way to reverse some of the long-term health disorders associated with OSA.

If you or someone you know is considering Continuous Positive Airway Pressure (CPAP) treatment, you'll need a sleep study to diagnosis whether or not you have sleep apnea, and a sleep specialist will recommend the correct CPAP machine, or treatment, for you.

Women, Wake Up: Sleep Apnea is Not Just a Male Disorder

Earlier this year, a particularly alarming statistic came out of Valme University Hospital in Seville, Spain, where researchers found that women with untreated severe OSA are three and a half times more likely to die from cardiovascular disease than women without OSA. (Read a summary of the study here.)

Since then, more research has been published showing high rates of sleep apnea in women,  as well as increasing links between OSA and age, obesity and hypertension.

In one new study published in August, researchers from Uppsala and Umeå University in Sweden analyzed 400 women between the ages of 20 and 70 years. They found that OSA was present in 50 percent of ALL the women participants aged 20 to 70 years.

They also found that 80 percent of women with hypertension and 84 percent of obese women suffered from sleep apnea. Of the obese women, 31 percent between age 55 and 70 had severe sleep apnea.

The alarming high percentages show that this should be a wake-up call to women.  Sleep apnea is not just a male disorder. Women—especially those with hypertension and/or obesity—need to wake up to the dangers of OSA and seek treatment if diagnosed with it.

Even Dr. Karl Franklin, lead author of the Swedish study, was surprised by the findings. He said, “We were very surprised to find such a high occurrence of sleep apnea in women, as it is traditionally thought of as a male disorder. These findings suggest that clinicians should be particularly aware of the association between sleep apnea and obesity and hypertension, in order to identify patients who could also be suffering from the sleeping disorder.

I agree wholeheartedly with Dr. Franklin, and add to his point that individuals, not just doctors, also need to be aware and speak up if they suspect they may have sleep apnea and related conditions. Read a summary of the study.

A few more recent studies showing OSA’s link to women’s health issues:

A study published in the September issue of the journal Obstetrics & Gynecology out of the University of South Florida found that babies born to obese women with OSA were more likely to be admitted to the neonatal intensive care unit than babies born to women without OSA. In addition, the women with OSA were more likely to develop a high blood pressure condition during pregnancy known as preeclampsia, and to deliver their babies by cesarean section.

Read the study, entitled, “Sleep apnea in obese pregnancy women linked to poor maternal and neonatal outcomes.”

In another study also published in September, sleep apnea in women has been linked to overactive bladder syndrome.

Researchers from the Hospital del Mar in Barcelona, Spain gave 72 women a questionnaire regarding their bladder control and four specific symptoms. According to the results, 62 of the women polled were diagnosed with obstructive sleep apnea (OSA). Further, the women with OSA scored higher on the questionnaire for the prevalence of bladder control symptoms, and the discomfort related with these symptoms.

More research is needed, but clearly, evidence is mounting showing the link between women and sleep apnea, and related disease and disorders. With one in four women over age 65 suffering from sleep apnea, according to the National Sleep Foundation, every woman who believes she is suffering from a sleep disorder-related condition should learn more and get checked out by a qualified sleep doctor. Many women are selfless caretakers, and will put their own worries or needs aside to take care of the needs of others. But don’t wait: Your health is the most important thing, and the healthier you are, the more productive you’ll be and the better you can care for your loved ones.

How do you know you may have obstructive sleep apnea? Some common symptoms include snoring, paused breathing during sleep and excessive sleepiness during the day. If you or someone you know is waking during the night gasping for air, that is a signal to seek diagnosis. Increased blood pressure is another sign you may have sleep apnea. For further study, read “Women and Sleep”  on the National Sleep Foundation website.

When you go for an exam, be specific with your doctor about the symptoms you are experiencing. While sleep apnea is more common in men, OSA increases in women after age 50. Many times, obstructive sleep apnea can be misdiagnosed in women as chronic fatigue, insomnia, depression, or some other non-specific condition. Also, some doctors still associate sleep apnea more with men than women, and are too quick to prescribe a medication, rather than do a full sleep disorder work up. Be  as clear and detailed as you can about your symptoms and what you are experiencing, and don’t wait —it could save your life.