Family support increases CPAP therapy in patients, new study says

Posted by David O. Volpi, MD, PC, FACS

Attention families of people with obstructive sleep apnea (OSA): you can make a positive difference when it comes to your family member’s use of a Continuous Positive Airway Pressure (CPAP) machine to treat their OSA.

According to new research published in May in the American Academy of Sleep Medicine’s journal, Sleep,    married people with OSA, or those living with a partner, showed better use of their CPAP machine after the first three months of treatment than OSA sufferers who were single.
Additionally, those who rated their family relationship quality as higher also showed better adherence to CPAP therapy.  The results were adjusted for potential confounding factors including age, gender, and body mass index.

Here’s a refresher on what OSA is, and how CPAP therapy can help: When you fall asleep, your muscles relax, and the soft palate at the back of the throat can sag. When this happens, the upper airway can become obstructed, causing the soft palate and uvula to vibrate, causing snoring.

When the airway is completely obstructed, breathing stops for a period of time, until the body is jerked awake in reaction. This is obstructive sleep apnea. OSA can cause interrupted breathing hundreds of times a night, usually around 20 seconds per pause.

This paused breathing causes waking through the night, preventing deep, restorative sleep. This often leads to a host of problems, from daytime sleepiness and reduced job performance, to hypertension, heart disease, mood, and memory problems.

A CPAP machine helps this condition by pumping a continuous flow of air into the nasal passages — via a mask worn at night — keeping the airway open, and preventing or greatly reducing snoring and paused breathing.

In addition to improving paused breathing and reducing snoring, CPAP treatment also reduces systemic inflammation, a common side effect of OSA. Systemic inflammation is inflammation of blood vessel tissues caused by foreign elements, such as pathogens or damaged cells.

Despite its effectiveness, the problem with CPAP therapy is that the patient has to wear an oxygen mask while they sleep at night. Many people find this uncomfortable, so they don’t wear it and subsequently don’t get the benefits of OSA treatment they need.

In an effort to increase CPAP therapy adherence, this study is great news. Family support from loved ones can increase a patient’s treatment and benefits.

If you or someone you know is considering or struggling with CPAP treatment, a qualified sleep specialist can recommend the correct CPAP machine, or one of the many non-surgical in-office treatments. Visit the eOs sleep apnea treatments page for more information.

Read the full study,  “Family support may improve adherence to CPAP therapy for sleep apnea.”

Can nasal surgery help CPAP therapy?

Written by David Volpi, M.D., P.C., F.A.C.S.

This month’s blog is for anyone who has obstructive sleep apnea (OSA) and is having trouble using—or refusing to use—a Continuous Positive Airway Pressure (CPAP) machine while sleeping.

CPAP machines help nighttime interrupted breathing by pumping a continuous flow of air into the nasal passages, keeping the airway open, and preventing or greatly reducing snoring and paused breathing. Still, many people are uncomfortable wearing the CPAP mask at night. Some feel claustrophobic or claim it causes dry mouth, nasal congestion and/or skin irritations.

There are two points I want to make about CPAP machines. One is: realize there are different types of masks and machines available, so take the time to choose one that’s right for you. Choose a small, quiet machine with a comfortable mask that fits you well. A heated humidifier attached to the CPAP machine can reduce throat dryness. Also, adjust titration so the CPAP pressure isn’t too high.

The second point I want to make, is that for some patients with nasal obstruction, a nasal surgery called septoplasty may help make CPAP therapy easier when combined with the above suggestions. An article in the January 2014 issue of The Laryngoscope  explains this first-of-its-kind study.

In response to the difficulty many OSA patients have using CPAP—what doctors call “problematic nonadherence”—three researchers wanted to find out if septoplasty, a surgery for nasal obstruction, would improve CPAP use and effectiveness.

For the study, head researchers Justin Poirier MD, Charles George MD, FRCPC, and Brian Rotenberg MD, MPH studied 18 patients over a six month period. Their average age was 52, 15 were males, and three were female. All the participants had been diagnosed with OSA, were prescribed nasal CPAP, yet were unable to tolerate CPAP treatment mostly due to nasal obstruction and a deviated septum.

The patients underwent septoplasty surgery with inferior turbinoplasty to improve breathing and sinus drainage. Following the surgery, data was collected regarding the patients’ CPAP usage per night. Patients were also asked to fill out the Nasal Obstruction Symptom Evaluation (NOSE) Scale questionnaire on how their post-surgery nasal obstruction felt.

The results of the study were encouraging. Before surgery, average patient CPAP usage was 0.5 hours per night. Pre-surgery NOSE Scale questionnaire data averaged 16.1 among the patients, with a maximum possible score of 20.

After surgery, the mean nightly CPAP usage was 3.9 hours per night (significant difference compared to preoperative data at P < .05). And the NOSE Scale score decreased to 5.4 (significant difference compared to preoperative data at P < .05).

In summary, the results show improved CPAP compliance rates following septoplasty surgery in OSA patients with documented nasal obstruction. That said, it’s important to keep in mind that septopasty surgery should be considered conservatively and for appropriate patients. Nasal surgery is not a cure-all for OSA, but along with CPAP and/or other therapies, could make a positive difference in easing OSA-related symptoms. Further, the results of this study offers some written proof of the effectiveness of septoplasty surgery for nasal obstruction and OSA treatment.

If you have been diagnosed with OSA, or are suffering from snoring and sleep issues, I urge you to get evaluated by a qualified ear, nose, and throat doctor. Some common symptoms of OSA include snoring, paused breathing during sleep and excessive sleepiness during the day. Increased blood pressure is another sign you may have sleep apnea.

Untreated OSA can result in poor sleep (for you and your partner), lack of focus, increased cardiovascular disease, and even death. So please get checked out. There are multiple options and minimally invasive techniques available today to treat OSA and other sleep disorders.

Read the full article entitled, “The effect of nasal surgery on nasal continuous positive airway pressure compliance” in the January 2014 issue of The Laryngoscope.

Say Hello to the Neurostimulator—an Alternative to CPAP Machines

I’ve been a practicing ear, nose, and throat specialist for more than 20 years, and one thing I know for certain about my obstructive sleep apnea (OSA) patients is—they have to do the treatments in order to get better.

The problem is that some OSA patients who would benefit from Continuous Positive Airway Pressure (CPAP) machines can’t or won’t use it because they find it uncomfortable, even though CPAPs have proven to be very effective in increasing oxygen flow and reducing apneic events that result in snoring.

But thankfully, medical advances are happening almost weekly, and so it is with sleep apnea diagnosis and treatment. One study that has me particularly excited recently appeared in the New England Journal of Medicine.  It was also written about in The New York Times by Catherine Saint Louis.

Inspire Medical Systems, based in Minneapolis, Minnesota, has developed a something called the neurostimulator to treat OSA. The pacemaker-like device is surgically implanted in the chest, and at night, the device sends regular electric impulses to a nerve inside the jaw. These electric impulses cause the tongue to move forward during inhalation, opening up the airway, improving air flow and reducing breathing pauses. 

Inspire Medical Systems funded a study to test the neurostimulator. Doctors surgically implanted remote-controlled neurostimulators in 126 patients, and activated them at night as the patients slept. After one year, patients experienced a marked decline in breathing pauses—from 29.3 episodes per hour to nine per hour, on average. Dangerous drops in blood oxygen levels also declined, from 25.4 per hour to 7.4 per hour, on average. At one year, 86 percent of patients said they use the neurostimulator on a daily basis, and two of the 126 patients stopped using in at night. Sleep apnea worsened in about 20 patients using the device, but doctors are not yet sure why.

The second phase also showed indications that the neurostimulator is effective in OSA treatment. In 46 patients who showed that the treatment was helping their OSA after one year, some were told to continue with the therapy or have it withdrawn for one week. Not surprisingly, those who continued the neurostimulator therapy showed little change in the number of breathing pauses per hour or drops in blood oxygen levels. But in the patients no longer using the therapy, the number of breathing pauses increased sharply, from 7.6 per hour to 25.8 per hour, on average. And the episodes of blood oxygen level drops rose from 6 per hour to 23 per hour, on average.

While more research and study is needed, the results are truly encouraging that upper airway neurostimulator therapy may soon be an effective and welcome alternative for OSA treatment, especially for those patients who have difficulty with CPAP masks and machines.

Read the full article entitled, “Upper-Airway Stimulation for Obstructive Sleep Apnea” in The New England Journal of Medicine.

Sleep Better — Get Smart about Your Smartphone

By Dr. David O. Volpi, M.D.

Smartphones, iPads, and other personal electronic devices are great ways to communicate and entertain ourselves, but they may also be negatively impacting the quality and quantity of our sleep.

As personal electronic devices have become more ubiquitous, the bright-light emitting screens that allow the use of mobile devices in dimly lit rooms have become a more common reason for sleep disruption, whether users realize it or not.

Why is that? Melatonin is a hormone produced by the pineal gland at night and when it is dark. It is a “timer” that tells the body that it is nighttime, and time to go to sleep. Exposure to light at night, such as that in the brightly-lit screens of many personal mobile devices, can interfere with melatonin, the hormone that helps control our sleep and wake cycles.

But rest easier: New research from the Mayo Clinic in Scottsdale, AZ explains a way to reduce the impact of electronic devises on sleep cycles.

Lois Krahn, M.D., a psychiatrist and sleep expert at the Mayo Clinic and co-author of the study said, “In the old days, people would go to bed and read a book. More commonly, people go to bed and they have their tablet on which they read a book or newspaper or look at material. The problem is it's a lit device, and how problematic is the light source from the mobile device?"

That question prompted Dr. Krahn to wonder, is the light from screens always a negative factor for sleep?" To find out, Krahn and his colleagues experimented with two tablets and a smartphone in a dark room, using a meter on its most sensitive setting to measure the light the devices emitted at various settings when held various distances from a person's face.

They discovered that when the brightness settings were lowered and the devices were held just over a foot from a user's face, it reduced the risk that the light would be bright enough to suppress melatonin secretion and disrupt sleep.

Explains Krahn, “We found that only at the highest setting was the light over a conservative threshold that might affect melatonin levels. If it's at the mid setting or at a low setting, it's bright enough to use."

The new Mayo Clinic research, which was presented in June at SLEEP 2013, the 27th annual meeting of the Associated Professional Sleep Societies LLC, in Baltimore, Md., also suggests things you can do to help prevent screen light from interfering with melatonin and affecting sleep.

These tips include dimming the smartphone or tablet brightness settings and holding the device at least 14 inches from your face while using it.

Other general tips include moving the TV and computer out of the bedroom, or at the very least, do not watch TV or work on the computer to bedtime.

With so many electronic distractions in our lives, it's important to re-claim the bedroom for its intended purpose: rest, relaxation, and sleep.

Untreated Sleep Apnea: The Quiet Danger on the Road

By Dr. David O. Volpi

It is common knowledge that untreated sleep apnea can have dire health effects, but researchers in England found out that loss of sleep also increases a person’s risk of nodding asleep at the wheel, and getting in a car accident. That endangers not only the person suffering from the sleep disorder, but any person driving around them at any given time.

The study, which was organized by the European Respiratory Society and the European Sleep Research Society, and presented April 12, 2013 at the Sleep and Breathing Conference in Berlin, determined that people with untreated sleep apnea are more likely to fail a driving simulator test, and report nodding asleep while driving.

Let’s review: What is sleep apnea?

Sleep apnea is a breathing disorder that causes a person’s breathing during sleep to be paused and/or shallow. The pauses generally last 10 to 20 seconds, and in severe cases, can occur hundreds of times a night. With obstructive sleep apnea (OSA), the airway is blocked and/or collapses while sleeping. Air squeezing by the blockage can cause loud snoring and interrupted sleep.

As a result of the paused breathing and/or snoring, many sleep apnea sufferers are woken up throughout the night and spend more time in light sleep, rather than deep, restful REM (rapid eye movement) sleep. This chronic sleep deprivation results in daytime sleepiness, and can negatively affect job performance, mood, reflexes, concentration, and it can lead to hypertension, heart disease, and memory problems.

Testing and results of the study

To determine the effect of untreated sleep apnea on driving, the researchers conducted two separate studies. The first was a driving simulation test where 133 patients with untreated sleep apnea and 89 without sleep apnea were asked to “drive” 90 km—about 55 miles.

Various criteria was recorded, including the participants’ ability to complete the driving distance, their time spent in the middle lane, and any participation in an unprovoked crash or a “veer event” crash.

The results of the driving simulation test showed that:

• Patients with untreated sleep apnea were more likely to fail the driving simulation test—24 percent of the sleep apnea patients failed the test, compared to 12 percent of those without sleep apnea.
• In addition, many patients with untreated sleep apnea were unable to complete the test at all, had more unprovoked crashes, and were unable to follow the clear driving instructions given at the beginning of the simulation test.

In the second study, 118 people with untreated sleep apnea and 69 without sleep apnea completed a questionnaire about their driving behavior, and also took the 90 driving test on the simulator.
The results showed that:

• 35 percent of those with untreated sleep apnea admitted to nodding asleep while at the wheel, and 38 percent of this same group failed the driving simulation test.
• By comparison, only 11 percent of people without sleep apnea said they have nodded off while driving, and none of this group failed the simulator test.

Key differences in the reasons for failure

While some people in the control group (those without sleep apnea) also failed the driving simulator test, the researchers noted key differences in why they failed the test:

• 13 people with untreated sleep apnea did not finish the test because they fell asleep or veered completely off the road.
• 5 people with untreated sleep apnea failed because they spent more than 5 percent of the study outside the lane they had been instructed to stay in.

But in the control group, no one failed the simulation for either of these reasons. Again, no one in the “without sleep apnea” group failed the driving simulation due to falling asleep, veering completely off the road, or driving outside the lane.

Dan Smyth of Sleep Apnea Europe noted, "The dangers of untreated sleep apnea and driving are highlighted in both studies. These studies give weight to the need for provision of sufficient resources for early diagnosis and treatment.

While further investigation is needed to examine the reasons for failure of the simulator tests, I acknowledge the researchers for bringing light to this very dangerous side effect of untreated sleep apnea. of sleep apnea, where effective treatment ensures a return to acceptable risk levels for road users."

Are you at risk for sleep apnea?

So how do you know you may have obstructive sleep apnea? Some common symptoms include snoring, paused breathing during sleep and excessive sleepiness during the day. Increased blood pressure is another sign you may have sleep apnea.

While sleep apnea is more common in men, OSA increases in women after age 50. Being overweight may also increase a woman’s risk of having sleep apnea. Menopausal women are three and a half times more likely to get OSA, possible due to reduced amounts of progesterone.

If you experiencing one or more of the above sleep apnea symptoms on a regular basis, see a qualified sleep doctor to get diagnosed and treated properly. There are multiple options and minimally invasive techniques available today to treat your sleep disorder.

A Good Night’s Sleep Can Be a Matter of Life and Death

Over the past three years, I have been writing the Wake Up! You’re Snoring blog with two main objectives: first, to educate you, the public, about sleep disorders, and second, to provide compelling reasons—preferably scientific evidence—why a person who may have a sleep disorder should get diagnosed and, if necessary, properly treated.

There is no shortage of scientific studies being released on a regular basis showing links between obstructive sleep apnea (OSA), insomnia, and other sleep disorders, and myriad negative health conditions, from daytime sleepiness to increased depression.

I wasn’t surprised to see a new study showing a link between insomnia, the loss of hope, and an increased risk of suicide. In a study led by Dr. W. Vaughn McCall, chair of the Medical College of Georgia at Georgia Regents University, researchers studied the mental state of 50 depressed patients between the ages of 20 and 80. More than half of the patients had attempted suicide, and most were taking an antidepressant.

It is established that insomnia and nightmares often go hand-in-hand, and are both known risk factors for suicide. The new study reaffirms that link, but researchers also wanted to find out what effect feelings of hopelessness about sleep had on suicide risk.

In the study, the researchers specifically focused on the relationship between insomnia and suicide risk by asking questions about dysfunctional beliefs about sleep, such as, “Do you think you will ever sleep again?” The scientists used psychometric testing to objectively measure the mental states and personalities of the 50 depressed patients.

Dr. McCall published the results of the study in the Journal of Clinical Sleep Medicine, the journal of the American Academy of Sleep Medicine. In the report, Dr. McCall stated, “It turns out insomnia can lead to a very specific type of hopelessness, and hopelessness by itself is a powerful predictor of suicide.” Dr. McCall also said, “The likelihood of being suicidal at least doubles when insomnia is a symptom.”

McCall and his colleagues have, in effect, discovered a new predictor for suicidal thinking. But why the link between lack of sleep and suicidal thoughts? Dr. McCall explained that, “It turns out insomnia can lead to a very specific type of hopelessness, and hopelessness by itself is a powerful predictor of suicide.” He continued, “If you talk with depressed people, they really feel like they have failed at so many things. It goes something like, ‘My marriage is a mess, I hate my job, I can’t communicate with my kids, I can’t even sleep.’ There is a sense of failure and hopelessness that now runs from top to bottom, and (insomnia) is one more thing. It was this dysfunctional thinking — all these negative thoughts about sleep — that was the mediating factor that explained why insomnia was linked to suicide,” said McCall.

The significance of this study, like many others, is that it not only educates people about the risks associated with insomnia and other sleep disorders, but it challenges the medical community to look at things a little differently when diagnosing and treating.

In this case, examine lack of sleep and insomnia when treating depression and suicidal thinking.  The finding also is a reminder to physicians that depressed patients who report increased sleep problems should be asked if they are having suicidal thoughts, McCall said.

If you’re having trouble sleeping, here are some tips to increase your chances of getting a good night’s sleep.

• Use the bedroom for sleep. With so many electronic distractions in our lives, it’s important to re-claim your bedroom for its intended purpose: rest and sleep. Move the TV and computer out of the bedroom, or at the very least, do not watch TV, work on the computer or check your blackberry close to bedtime.
• Stick to a bedtime routine. Try to go to sleep before 10:00 pm at night, and wake up around the same time every day, even on weekends. Try to keep to within 20 minutes of the same time each morning and night.
• Do activities that will get you ready for bed. Before bed, do activities that will promote sleepiness, such as a taking a warm bath, or reading a book or magazine.
• Maintain a cool temperature in your bedroom. A cool but comfortable temperature is ideal for sleep. Too warm and you will be fitful, too cold however can be uncomfortable and disturb your sleep.
• Exercise regularly but not after the late afternoon. Even though exercise helps regulate sleep, rigorous exercise causes endorphins in the body to circulate which can have a stimulant effect, and keep you awake longer at night.
• Stay away from caffeine at night. The effects of caffeine are different from person to person, and may last hours after your last cup of coffee, so make your last cup of coffee, regular tea or soda earlier in the day.
• Avoid alcohol and medicines that make you drowsy. Even if you think it is helping you fall asleep initially, alcohol and medicines that makes you drowsy may affect your sleep throughout the night.

Remember, people need an average of 7-8 hours of restful sleep to fully take advantage of its restorative power and avoid daytime symptoms of fatigue. If a regular, peaceful routine incorporating the tips above doesn’t help you start sleeping peacefully throughout the night, contact your doctor. You may have a more serious cause of sleeplessness such as snoring, sleep apnea or chronic insomnia. Getting treated could prevent heart disease, hypertension and stroke.

Snoring a Top Predictor of Heart Attacks and Strokes

By Dr. David O. Volpi

I read a study recently that I immediately knew I had to make you aware of.

Researchers at Henry Ford Hospital in Detroit found that snoring is a bigger risk factor for heart disease, including stroke and heart attacks, than being overweight, having high cholesterol, and even smoking! Yes, you read that right—snoring is an even bigger risk factor for heart disease.

The study, which was submitted to The Laryngoscope journal, is the first of its kind to show a link between snoring and heart disease, similar to other risk factors, such as sleep apnea, obesity, smoking and high cholesterol are also linked to heart disease.

Snorers showed arterial damage

For the study, Dr. Robert Deeb, MD, and senior study author Karen Yaremchuk, MD, reviewed the data of 913 patients, all between the ages of 18 and 40, who had been evaluated by the Henry Ford sleep center between December 2006 and January 2012.

The researchers noticed that the carotid arteries—the arteries that supply oxygen-rich blood to the brain—had thickened among the snorers, indicating that arterial damage had occurred due to snoring.

The researchers hypothesized that the thickening of the artery walls could have been due to the trauma and inflammation caused by snoring. But previous research on sleep apnea and artery disease has found the opposite: arterial damage comes first, reducing the oxygen level in the blood, leading to interruptions in breathing. The thickening of the arteries may also be contributing to the snoring in the patients.

Even more interesting: The snorers’ arterial walls had thickened, even though none of the patients had been diagnosed with obstructive sleep apnea (OSA). While OSA often develops from snoring and has been known as an indicator of cardiovascular disease, there’s been little evidence until now to prove that arterial damage can actually begin with snoring.

What these results mean

So what are the medical implications of the Henry Ford study? Let’s review coronary artery disease for a moment. Coronary artery disease (CAD), also known as atherosclerosis, occurs when waxy plaque builds up on the inner walls of the arteries.

Over time, the arterial walls thicken and stiffen, restricting blood flow to the heart and/or brain. It is commonly know that CAD is a precursor to conditions such as heart attack, stroke, and heart failure.

The results of the Henry Ford study—that the carotid arteries had thickened among the snorers, is important to pay attention to because it means that snoring, not just OSA, is a high risk factor for coronary artery disease, heart disease, and other related conditions.

Drs. Deeb and Yaremchuk’s research is groundbreaking because arterial blockage and other forms of heart disease are usually detected only after significant permanent damage has been done.

This new research should encourage snorers—and those who love them—to visit a doctor to discuss cardiovascular health and stroke prevention, and get properly diagnosed and treated.

The research is clear that doctors should add snoring to the list of coronary artery disease risk factors, along with high blood pressure, high cholesterol, diabetes, smoking and family history. Perhaps if patients and their doctors considered snoring a serious health threat and treated it accordingly, there would be a great reduction in heart disease.

Women with Sleep Apnea Show Higher Brain Damage, Anxiety than Men

An estimated 18 million Americans have obstructive sleep apnea (OSA), including one in four women over 65, according to the National Sleep Foundation.

And several recent studies have linked OSA to health disorders specifically in women. Sleep apnea has been linked to dementia in older women,  and another observational study found that women with untreated severe OSA are 3.5 times more likely to die from cardiovascular disease than women without OSA.

Here’s another reason for women to take sleep apnea seriously: A first-of-its-kind study out of the UCLA School of Nursing discovered that women with sleep apnea are more likely to suffer a higher degree of brain damage than men with sleep apnea.

What is obstructive sleep apnea? OSA is a disorder that occurs when a person's breathing is repeatedly interrupted during sleep, sometimes hundreds of times a night. During each obstruction, the oxygen level in the blood drops, which over time, causes myriad health problems. For people with sleep apnea, the combination of disturbed sleep and oxygen starvation may lead to hypertension, heart disease and mood and memory problems, among other disorders.

The new UCLA study

UCLA has been on the cutting edge of sleep apnea research. About 10 years ago, the same UCLA research team that conducted the new study was the first to show that men with OSA have damage to their brain cells.

For the latest multi-year study, entitled "Sex Differences in White Matter Alterations Accompanying Obstructive Sleep Apnea,” the researchers studied patients diagnosed with OSA at the UCLA Sleep Laboratory. They compared the nerve fibers in the patients' brains, known as “white matter,” to the nerve fibers of people without OSA or other sleep problems. The goal was to find the differences in brain damage, if any, between men and women with OSA.

Results of the study

The researchers found that women are actually more affected by sleep apnea than men. Additionally, women with OSA have more severe brain damage than men suffering from a similar condition. The women with sleep apnea also showed higher levels of depression and anxiety symptoms.

Specifically, the study found that women were impacted in the cingulum bundle and the anterior cingulate cortex areas in the front of the brain involved in decision-making and mood regulation.

Based on the results, chief investigator Paul Macey said, “Doctors should consider that OSA in women may be more problematic and therefore need earlier treatment in women than men.”

With the results of this study as a foundation, the next step is for the researchers to find out if treating sleep apnea can help the brain.

In a “chicken or egg” scenario, did the OSA cause the brain damage, or did the brain damage cause the OSA?  Or did the common conditions, such as depression, dementia or cardiovascular issues cause the brain damage, which in turn leads to sleep apnea?

The study and resulting questions are fascinating, and one thing is for sure: both men and women who are having trouble sleeping should get checked for obstructive sleep apnea and other sleep disorders.

Researchers estimate that up to 85 percent of people with severe sleep apnea have not been diagnosed yet.

Many times, sleep apnea can be misdiagnosed as chronic fatigue, insomnia, depression, or some other non-specific condition, so be specific about the symptoms you are experiencing.

Don't wait to get checked—it could save your life, or someone you love.

For more information, read the article, “Women with sleep apnea have higher degree of brain damage than men, UCLA study shows.”

Veterans with Sleep Apnea: A Growing Human Issue

Whether or not you personally know someone who has served in Iraq, Afghanistan or someplace else on foreign soil, our returning veterans deserve our help and attention. While many have the scars of physical injury, many more veterans bear silent scars. A little known fact but of increasing concern in the medical community is that a growing number of veterans are suffering from obstructive sleep apnea (OSA), and its symptoms can be devastating for our returning war heroes as they readjust to civilian life

Consider these statistics: According to the U.S. Department of Veterans Affairs (VA), one out of every five war veterans has been diagnosed with OSA — compared with only five out of 100 civilians in the general population. And between 2008 and 2010, the number of veterans who received medical benefits related to sleep apnea grew by 61 percent, from 39,145 cases in 2008 to 63,118 cases in 2010.

These numbers beg the question: Why do war veterans suffer from sleep apnea more than non-war veterans and civilians? Some VA doctors believe that it is due to the high number of repeat deployments to Iraq and Afghanistan — soldiers are being exposed to higher levels of dust, smoke, stress and violence.

But what is at the core of this connection between war, OSA and other related conditions, such as daytime sleepiness, memory loss, a decrease in work productivity, obesity, heart disease, diabetes, and hypertension. Researchers at the Wayne State University (WSU) School of Medicine are beginning to find out.

Since the mid-2000s, WSU researchers have been studying 145 American immigrants who left Iraq before the 1991 Gulf War, and 205 who fled Iraq after the Gulf War began. All lived in the Detroit area at the time, and were asked about socio-demographics, pre-migration trauma, how they rated their current health, physician-diagnosed and physician-treated OSA, and any somatic and psychosomatic disorders.

The study’s lead investigator, Bengt Arnetz, M.D., Ph.D., M.P.H., School of Medicine professor of occupational and environmental health, and deputy director of the Institute of Environmental Health Sciences at Wayne State said, “It may be the stress of war that leads to fractured sleep, and that no one had explored this possible link before, although basic research suggests it as plausible.”

The results of the study are published in the October 2012 issue of Psychosomatic Medicine in the article, "Obstructive Sleep Apnea, Post-traumatic Stress Disorder, and Health in Immigrants.” The research showed that those who left Iraq after the war began and suffered from mental disorders such as post-traumatic stress disorder (PTSD) and depression, and self-rated their physical health as worse than their actual health, were 43 times more likely than pre-Gulf War immigrants to report OSA and later develop major chronic health issues, such as cardiovascular disease.

On the results, Arnetz said, “It's a known fact that the more exposure to violence you have, the more likely you are to report post-traumatic stress disorder (PTSD) and depression, and the worse your self-rated health is, the more likely your actual health will suffer in five to 10 years.” And I reiterate, those who were exposed to the violence of the war in Iraq were almost twice as likely to experience PTSD and depression, but also Obstructive Sleep Apnea and other chronic health conditions. I applaud Arnetz and his colleagues’ efforts, and encourage them to continue their studies so that we in the medical community can better understand, diagnose and treat war- and stress-related health conditions.

What about treatment? Diagnosing OSA in veterans can be trickier than non-veterans because of the possibility of other military-related medical conditions, such as PTSD. In addition, some military veterans suffering from OSA may underestimate the health benefits of restorative sleep, rather than be properly diagnosed and treated since its common during deployment to have fractured sleep patterns.

The good news is that there is more awareness of OSA than ever before, especially within the military. Back in February 2012, Ventus Medical, the company that makes Provent Therapy, announced that the U.S. Department of Veterans Affairs approved a multi-year, Federal Supply Schedule contract that would enable more veterans to get Provent Therapy treatment — a small, non-invasive nasal device for the treatment of obstructive sleep apnea (OSA).

This is good timing, considering that a substantial percentage of veterans don't accept or adhere to continuous positive airway pressure (CPAP) therapy, even though it is a safe and effective treatment. According to Richard B. Berry, M.D., Professor of Medicine at University of Florida, "There is a great need for access to new, clinically-proven therapies—particularly easy-to-use treatments — for the increasing number of veterans with obstructive sleep apnea."

As more and more Iraq and Afghanistan veterans are realizing their post-war health problems, and because many Vietnam veterans are getting older, the number of veterans applying for OSA-related disability benefits will only continue to rise in the coming years. While OSA is a chronic condition creating a significant burden on the Veterans Healthcare System — the VA spends upwards of $500 million a year to treat veterans with sleep apnea — I believe that it is our duty as a nation to provide proper OSA treatment to our veterans to prevent additional chronic health issues. To read more about the study, go to the Wayne State University website.

Women, Wake Up: Sleep Apnea is Not Just a Male Disorder

Earlier this year, a particularly alarming statistic came out of Valme University Hospital in Seville, Spain, where researchers found that women with untreated severe OSA are three and a half times more likely to die from cardiovascular disease than women without OSA. (Read a summary of the study here.)

Since then, more research has been published showing high rates of sleep apnea in women,  as well as increasing links between OSA and age, obesity and hypertension.

In one new study published in August, researchers from Uppsala and Umeå University in Sweden analyzed 400 women between the ages of 20 and 70 years. They found that OSA was present in 50 percent of ALL the women participants aged 20 to 70 years.

They also found that 80 percent of women with hypertension and 84 percent of obese women suffered from sleep apnea. Of the obese women, 31 percent between age 55 and 70 had severe sleep apnea.

The alarming high percentages show that this should be a wake-up call to women.  Sleep apnea is not just a male disorder. Women—especially those with hypertension and/or obesity—need to wake up to the dangers of OSA and seek treatment if diagnosed with it.

Even Dr. Karl Franklin, lead author of the Swedish study, was surprised by the findings. He said, “We were very surprised to find such a high occurrence of sleep apnea in women, as it is traditionally thought of as a male disorder. These findings suggest that clinicians should be particularly aware of the association between sleep apnea and obesity and hypertension, in order to identify patients who could also be suffering from the sleeping disorder.

I agree wholeheartedly with Dr. Franklin, and add to his point that individuals, not just doctors, also need to be aware and speak up if they suspect they may have sleep apnea and related conditions. Read a summary of the study.

A few more recent studies showing OSA’s link to women’s health issues:

A study published in the September issue of the journal Obstetrics & Gynecology out of the University of South Florida found that babies born to obese women with OSA were more likely to be admitted to the neonatal intensive care unit than babies born to women without OSA. In addition, the women with OSA were more likely to develop a high blood pressure condition during pregnancy known as preeclampsia, and to deliver their babies by cesarean section.

Read the study, entitled, “Sleep apnea in obese pregnancy women linked to poor maternal and neonatal outcomes.”

In another study also published in September, sleep apnea in women has been linked to overactive bladder syndrome.

Researchers from the Hospital del Mar in Barcelona, Spain gave 72 women a questionnaire regarding their bladder control and four specific symptoms. According to the results, 62 of the women polled were diagnosed with obstructive sleep apnea (OSA). Further, the women with OSA scored higher on the questionnaire for the prevalence of bladder control symptoms, and the discomfort related with these symptoms.

More research is needed, but clearly, evidence is mounting showing the link between women and sleep apnea, and related disease and disorders. With one in four women over age 65 suffering from sleep apnea, according to the National Sleep Foundation, every woman who believes she is suffering from a sleep disorder-related condition should learn more and get checked out by a qualified sleep doctor. Many women are selfless caretakers, and will put their own worries or needs aside to take care of the needs of others. But don’t wait: Your health is the most important thing, and the healthier you are, the more productive you’ll be and the better you can care for your loved ones.

How do you know you may have obstructive sleep apnea? Some common symptoms include snoring, paused breathing during sleep and excessive sleepiness during the day. If you or someone you know is waking during the night gasping for air, that is a signal to seek diagnosis. Increased blood pressure is another sign you may have sleep apnea. For further study, read “Women and Sleep”  on the National Sleep Foundation website.

When you go for an exam, be specific with your doctor about the symptoms you are experiencing. While sleep apnea is more common in men, OSA increases in women after age 50. Many times, obstructive sleep apnea can be misdiagnosed in women as chronic fatigue, insomnia, depression, or some other non-specific condition. Also, some doctors still associate sleep apnea more with men than women, and are too quick to prescribe a medication, rather than do a full sleep disorder work up. Be  as clear and detailed as you can about your symptoms and what you are experiencing, and don’t wait —it could save your life.

Less Than Six Hours Sleep/Night Increases Strokes

Lack of sleep and an increase in strokes. According to new research, the two conditions are very connected, even in otherwise healthy adults.

In early June, the University of Alabama at Birmingham released the results of a study that regularly sleeping less than six hours a night significantly increases the risk of stroke symptoms in middle-age to older adults who are of normal weight and at low risk for obstructive sleep apnea (OSA). That’s worth repeating: Less than six hours of sleep per night increases the risk of strokes in adults of normal weight and not at risk for OSA.

It seems that under six hours of sleep per night is the critical variable, but why? Let’s take a look at the study. The University of Alabama researchersfollowed 5,666 people  for up to three years who had no history of strokes or stroke-like symptoms, transient ischemic attacks (when blood flow to the brain stops for a brief period causing stroke-like symptoms), or high risk for OSA at the start of the study.

For a period of three years, the researchers followed and studied the subjects’ first stroke symptoms, stroke risk factors, depression symptoms, demographic information and other various health behaviors. What they found was—after adjusting for body-mass index (BMI)—there was a strong association between daily sleep periods of less than six hours and a greater incidence of stroke symptoms for middle-age to older adults, even beyond other risk factors. Interestingly, the researchers did not find any link between short sleep periods and stroke symptoms in overweight and obese participants.

Still, the connection between short sleep and strokes is worthy of great attention from the medical community and general public. I agree with the Alabama study’s lead author, Megan Ruiter, PhD., who said, “The results of the Alabama study provide a strong argument for increasing physician and public awareness of the impact of sleep as a risk factor for stroke symptoms, especially among persons who appear to have few or no traditional risk factors for stroke.”

It looks like the medical community is taking this message to heart. Another study announced in late July is going on at the Alberta Health Services and the University of Calgary.  There, Dr. Patrick Hanly of the university’s Hotchkiss Brain Institute is leading a study to learn more about the physiological connection between sleep apnea and stroke—specifically, the brain’s blood flow response in people with and without sleep apnea.

For the study, participants with sleep apnea stay overnight in the sleep laboratory at Calgary’s Foothills Medical Centre, where their breathing and cardiovascular responses are continuously monitored while they sleep. The next day, their brain blood flow response to reduced oxygen levels is assessed while they are awake. Then, the participants receive supplemental oxygen during sleep for two weeks, and are tested again to see if their cerebral defense mechanisms have improved. The researchers are also studying people without sleep apnea to see if their cerebral defense mechanisms function better than in those with sleep apnea. Hanly and team’s theory is that it is the lack of oxygen, or hypoxia, that people with sleep apnea experience during sleep that impairs the body’s normal defense mechanisms in the brain. A better understanding of this connection will lead to better prevention and treatment strategies.

I applaud the work of the Alabama and Calgary researchers. It’s time we all wake up to the health benefits of more–and better—sleep.

For more information, read the University of Alabama at Birmingham study, “Under 6 Hours of Sleep Tops Risks for Stroke in a Low-risk Population.”

Ready to Treat Your Sleep Apnea? You Have Options.

This month’s blog is for anyone who has been diagnosed with obstructive sleep apnea (OSA) and is currently using or considering using a Continuous Positive Airway Pressure (CPAP) machine while sleeping.

Many patients are not happy about the prospect of sleeping with an mask on. If you do opt for CPAP therapy, realize that CPAP machines have come a long way. If you’re adamant you do not want to use a CPAP mask, thankfully, you have options.

First, I want to briefly explain what obstructive sleep apnea does to a person’s nighttime breathing. When you fall asleep, your muscles relax, and the soft palate at the back of the throat can sag. When this happens, the upper airway can become obstructed, causing the soft palate and uvula to vibrate, causing snoring.

When the airway is completely obstructed, breathing stops for a period of time, until the body is jerked awake in reaction. This is obstructive sleep apnea. OSA can cause interrupted breathing hundreds of times a night, usually around 20 seconds per pause.

This paused breathing causes waking through the night, preventing deep, restorative sleep. This often leads to a host of problems, from daytime sleepiness and reduced job performance to hypertension,heart disease, mood and memory problems.

A CPAP machine helps this condition by pumping a continuous flow of air into the nasal passages, keeping the airway open, and preventing or greatly reducing snoring and paused breathing.

Many people don’t like wearing the nasal mask for CPAP therapy. Some feel claustrophobic or claim it causes dry mouth, nasal congestion or skin irritations. Realize there are different machines out there, so it’s important to choose the right machine for you—choose a small, quiet machine with a comfortable mask that fits you well. A humidifier attached to the CPAP machine can reduce throat dryness.

If CPAP therapy is not for you, there are some non-surgical treatment options. One of the latest is the Pillar Procedure, a safe, non-invasive treatment for mild to moderate OSA symptoms. During the Pillar Procedure, three tiny polyester implants are placed into the soft palate through a small delivery tool without incisions or stitches. Over the following weeks, the implants, together with the body's natural fibrotic response, stiffens the upper palate and creates structural support. This reduces the tissue vibration that causes snoring and the tissue collapse that causes obstructive sleep apnea. I do the Pillar Procedure at my Eos Sleep office, and it usually takes around 20 minutes.

Another is a more comfortable alternative to CPAP, called the Provent Device. This FDA-approved treatment involves a small nasal valve that fits into the nostrils and is secured by an adhesive bandage. The valve is powered by your own breathing and creates positive airway pressure much like CPAP, but does not require a machine or mask.

Bilevel Positive Airway Pressure (BiPAP) is similar to CPAP therapy, but the machine has two air pressure levels, one for breathing in and one for breathing out. The air pressure for breathing out is usually set lower than the incoming air, and you may find it more comfortable to breathe out against a lower air pressure.

Whatever OSA treatment option you choose, you owe it to yourself to seek proper treatment and use your chosen therapy regularly.  The benefits are great—snoring and paused breathing will be reduced or eliminated, helping you—and your partner—to sleep and feel better during the day.

Women and Sleep Apnea: At Greater Risk Than We Thought

A few months ago, my blog entitled, “Who’s Suffering More from Lack of Sleep — Men or Women?”  discussed “the sleep battle of the sexes,” specifically, who suffers more from sleep disorders — men or women? In that blog, I made the point that, while men are generally more likely to suffer from obstructive sleep apnea (OSA) than women, men are also more likely to get tested and treated for the disorder.

That’s not good, because we are learning that many more women than previously thought suffer from OSA, and leaving it unchecked can have dire consequences on a woman’s cardiovascular health.

I read a recent women and sleep apnea study out of Spain that said that women with untreated severe OSA are three and a half times more likely to die from cardiovascular disease than women without OSA. Three and a half times!

Thankfully, the study also showed that women who treat their severe sleep apnea at night with a technique called continuous positive airway pressure (CPAP) significantly reduce their risk of heart attack-related deaths to about the same risk level as women without OSA.

The study was conducted by Dr. Francisco Campos-Rodriguez, director of the sleep-disordered breathing unit at Valme University Hospital in Seville, Spain. To read a summary of the study, go to the Annals of Internal Medicine.

The research is a wake-up call to both patients and doctors because it is the first published results that link OSA to cardiovascular death in women, and that CPAP treatment can reduce OSA-related mortality risk.

It also shines a light on the need for more research regarding sleep apnea and women, as well as the need for women to take their symptoms seriously, and not just consider OSA “a man’s disease.”

What Women Should Know About Sleep Apnea

So how do you know you may have obstructive sleep apnea? Some common symptoms include snoring, paused breathing during sleep and excessive sleepiness during the day. Increased blood pressure is another sign you may have sleep apnea.

While sleep apnea is more common in men, OSA increases in women after age 50. According to the National Sleep Foundation, one in four women over age 65 have sleep apnea.

Being overweight also increases a woman’s risk of having sleep apnea. Menopausal women are three and a half times more likely to get OSA, possible due to reduced amounts of progesterone.

If you have any of the symptoms mentioned above, and suspect that you may have sleep apnea, please get checked out by a doctor who specializes in sleep disorders. Be specific about the symptoms you are experiencing. Many times, sleep apnea can be misdiagnosed in women as chronic fatigue, insomnia, depression, or some other non-specific condition.

Also, some doctors still associate sleep apnea more with men than women, and are too quick to prescribe a medication, rather than do a full sleep disorder work up. Again, to try and avoid misdiagnosis, go to a qualified sleep specialist and be specific about your symptoms. Don’t wait — it could save your life.

Why Home Sleep Testing is Revolutionizing Sleep Apnea Treatment

Although home sleep apnea testing equipment has be utilized for a few years, it wasn’t until recent findings presented at the American Thoracic Society 2010 International Conference confirmed that patients that used the home sleep test showed similar improvements in their obstructive sleep apnea (OSA) treatment as did patients who had their sleep testing performed in an overnight lab.

Prior to the findings of this study, it was commonly thought that patients would have the most successful treatment if they stayed overnight in a lab, because they would be spending more time with a technician who provides education of OSA and the importance of its treatment, which would improve the patient’s compliance using the standard CPAP (continuous positive airway pressure) device of their treatment once at home. Since many patients complain about the discomfort of the CPAP, compliance is difficult for many.

However, as this study found, of 300 patients who randomly either underwent their sleep testing in the lab or at home, 185 of them completed three months of follow-up treatment. The results of their OSA improvements using CPAP treatment where similar regardless of whether they had their sleep testing done in the lab or in the home.

The Manhattan Snoring and Sleep Center now offers home sleep testing equipment to qualified patients, and has found similar results as this study with its own patients who either under go sleep testing at the center’s overnight lab or at home.

A home sleep test is used only to diagnose sleep apnea, and obstructive sleep apnea is the most common type, as well as the most serious. It is caused by an obstructed upper airway in which soft tissue of the palate, throat or tongue blocks the flow of air as a person struggles to breathe. Since OSA symptoms can lead to severe health conditions, it is very serious and important that patients receive expert medical care and guidance. There are other physical causes of snoring and apnea, and since home sleep tests only diagnose apnea, a patient should have a thorough physical exam first to see if the test is right for them or if a different line of treatment is necessary. Even if sleep apnea is suspected, there are other factors that may make a test in an overnight sleep lab necessary.

Visit the Manhattan Snoring and Sleep Center website for more information about the home sleep test. If you suspect that you have sleep apnea or if snoring is keeping you from getting a good night’s sleep, contact us today to schedule an appointment.